Contrasting effects of estradiol and 17ß-aminoestrogens on blood clotting time in rats and mice
Por:
Lemini C., Franco Y., Avila Ma.E., Jaimez R.
Publicada:
1 ene 2005
Resumen:
Estrogens have been associated with thromboembolic events. Our group has described the anticoagulant effect of 17?-aminoestrogens in rodents, potentially new alternative estrogenic agents without thrombogenic risk. This work compares the contrasting effects of estradiol and the 17?- aminoestrogens (prolame, butolame, and pentolame) on blood clotting time. Ovariectomized CD1 mice received a single injection of 17?-aminoestrogens, estradiol (20 to 80 mg/kg), or vehicle. Estradiol decreased blood clotting time from -10% to -25% (48 h; P<0.01) and 17?-aminoestrogens increased it, differing in latency (?12 h; +48%, P<0.01) and duration (?72 h +58%, P<0.01). In male Wistar rats, similar effects (pentolame +45%; estradiol -31%; P<0.01) were observed 48 h after five consecutive daily injections of 1000 ?g/animal/day. The maximum procoagulant effect of estradiol was obtained after 72 h with 10 ?g/animal/day (-45%; P<0.01). 17?-Aminoestrogens always produced opposite effects to those of estradiol on blood coagulation. © 2005 Published by Elsevier B.V.
Filiaciones:
Departamento de Farmacología, Facultad de Medicina, Ciudad Universitaria, Apdo. Postal 70-297, México, D.F., C.P. 04510, Mexico
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