Neurogenesis in the subventricular zone following transcranial magnetic field stimulation and nigrostriatal lesions
Por:
Arias-Carrión O., Verdugo-Díaz L., Feria-Velasco A., Millán-Aldaco D., Gutiérrez A.A., Hernández-Cruz A., Drucker-Colín R.
Publicada:
1 ene 2004
Resumen:
Neurogenesis continues at least in two regions of the mammalian adult brain, the subventricular zone (SVZ) and the subgranular zone in hippocampal dentate gyrus. Neurogenesis in these regions is subjected to physiological regulation and can be modified by pharmacological and pathological events. Here we report the induction of neurogenesis in the SVZ and the differentiation after nigrostriatal pathway lesion along with transcranial magnetic field stimulation (TMFS) in adult rats. Significant numbers of proliferating cells demonstrated by bromodeoxyuridine-positive reaction colocalized with the neuronal marker NeuN were detected bilaterally in the SVZ, and several of these cells also expressed tyrosine hydroxylase. Transplanted chromaffin cells into lesioned animals also induced bilateral appearance of subependymal cells. These results show for the first time that unilateral lesion, transplant, and/or TMFS induce neurogenesis in the SVZ of rats and also that TMFS prevents the motor alterations induced by the lesion. © 2004 Wiley-Liss, Inc.
Filiaciones:
Arias-Carrión O.:
Departamento de Neurociencias, Instituto de Fisiologia Celular, UNAM, México D.F., Mexico
Verdugo-Díaz L.:
Departamento de Fisiología, Facultad de Medicina, UNAM, México D.F., Mexico
Feria-Velasco A.:
U. de Morfologia de Alta Resolucion, CUCBA, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico
Millán-Aldaco D.:
Departamento de Neurociencias, Instituto de Fisiologia Celular, UNAM, México D.F., Mexico
Gutiérrez A.A.:
Unidad de Terapia Celular, Centro Nacional de Rehabilitacion, México D.F., Mexico
Hernández-Cruz A.:
Departamento de Biofísica, Instituto de Fisiologia Celular, UNAM, México D.F., Mexico
Drucker-Colín R.:
Departamento de Neurociencias, Instituto de Fisiologia Celular, UNAM, México D.F., Mexico
Departamento de Neurociencias, Instituto de Fisiologia Celular, UNAM, Apdo. Postal 70-600, 04510 México D.F., Mexico
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