Induction of protection against porcine cysticercosis by vaccination with recombinant oncosphere antigens
Por:
Flisser A., Gauci C.G., Zoli A., Martinez-Ocaña J., Garza-Rodriguez A., Dominguez-Alpizar J.L., Maravilla P., Rodriguez-Canul R., Avila G., Aguilar-Vega L., Kyngdon C., Geerts S., Lightowlers M.W.
Publicada:
1 ene 2004
Resumen:
Two recombinant Taenia solium oncosphere antigens, designated TSOL18 and TSOL45-1A, were investigated as vaccines to prevent transmission of the zoonotic disease cysticercosis through pigs. Both antigens were effective in inducing very high levels of protection (up to 100%) in three independent vaccine trials in pigs against experimental challenge infection with T. solium eggs, which were undertaken in Mexico and Cameroon. This is the highest level of protection that has been achieved against T. solium infection in pigs by vaccination with a defined antigen. TSOL18 and TSOL45-1A provide the basis for development of a highly effective practical vaccine that could assist in the control and, potentially, the eradication of human neurocysticercosis.
Filiaciones:
Flisser A.:
Direction de Investigatión, Hosp. General Dr. M. Gea Gonzalez, SSA, Mexico DF, Mexico
Depto. de Microbiol. y Parasitologia, Facultad de Medicina, UNAM, Mexico DF, Mexico
Gauci C.G.:
Veterinary Clinical Centre, University of Melbourne, Werribee, Vic., Australia
Zoli A.:
Department of Animal Production, Faculty of Agriculture, University of Dschang, Dschang, Cameroon
Martinez-Ocaña J.:
Direction de Investigatión, Hosp. General Dr. M. Gea Gonzalez, SSA, Mexico DF, Mexico
Garza-Rodriguez A.:
Direction de Investigatión, Hosp. General Dr. M. Gea Gonzalez, SSA, Mexico DF, Mexico
Dominguez-Alpizar J.L.:
Facultad de Medicina Veterinaria, Merida, Yucatan, Mexico
Maravilla P.:
Direction de Investigatión, Hosp. General Dr. M. Gea Gonzalez, SSA, Mexico DF, Mexico
Rodriguez-Canul R.:
CINVESTAV, Merida, Yucatan, Mexico
Avila G.:
Depto. de Microbiol. y Parasitologia, Facultad de Medicina, UNAM, Mexico DF, Mexico
Aguilar-Vega L.:
Depto. de Microbiol. y Parasitologia, Facultad de Medicina, UNAM, Mexico DF, Mexico
Kyngdon C.:
Veterinary Clinical Centre, University of Melbourne, Werribee, Vic., Australia
Geerts S.:
P. Leopold Inst. Tropische Geneesk., Antwerp, Belgium
Lightowlers M.W.:
Veterinary Clinical Centre, University of Melbourne, Werribee, Vic., Australia
Veterinary Clinical Centre, University of Melbourne, 250 Princes Highway, Werribee, Vic. 3030, Australia
All Open Access, Bronze
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