Trypanocidal constituents in plants 3. Leaves of Garcinia intermedia and heartwood of Calophyllum brasiliense
Por:
Abe F., Nagafuji S., Okabe H., Akahane H., Estrada-Muñiz E., Huerta-Reyes M., Reyes-Chilpa R.
Publicada:
1 ene 2004
Resumen:
The constituents of the leaves of Garcinia intermedia and heartwood of Calophyllum brasiliense were investigated based on their trypanocidal activity against epimastigotes of Trypanosoma cruzi, the etiologic agent of Chagas' disease. As the active components, the polyisoprenylated benzophenone derivative guttiferone A and the xanthone 8-desoxygartanin were isolated along with the biflavonoids podocarpusflavone A and amentoflavone, and friedelin from the former. Three xanthones, jacareubin, 6-deoxyjacareubin, and 1,3,5,6- tetrahydroxy-2-(3-methyl-2-butenyl)xanthone from the latter showed activity. The trypanocidal activity of these compounds against trypomastigotes, an infectious form of T. cruzi, was examined as well as gossypol, berberine chloride, and harmine for comparison. © 2004 Pharmaceutical Society of Japan.
Filiaciones:
Abe F.:
Faculty of Pharmaceutical Sciences, Fukuoka University, Jonan-ku, Fukuoka 814-0180, Japan
Nagafuji S.:
Faculty of Pharmaceutical Sciences, Fukuoka University, Jonan-ku, Fukuoka 814-0180, Japan
Okabe H.:
Faculty of Pharmaceutical Sciences, Fukuoka University, Jonan-ku, Fukuoka 814-0180, Japan
Akahane H.:
Fukuoka University, School of Medicine, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan
Estrada-Muñiz E.:
Institute of Chemistry, National University of Mexico, Ciudad Universitaria, 04510, Mexico D.F., Mexico
Huerta-Reyes M.:
Institute of Chemistry, National University of Mexico, Ciudad Universitaria, 04510, Mexico D.F., Mexico
Reyes-Chilpa R.:
Institute of Chemistry, National University of Mexico, Ciudad Universitaria, 04510, Mexico D.F., Mexico
All Open Access; Bronze
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