Resin glycosides from the roots of Ipomoea tyrianthina and their biological activity
Por:
Mirón-López G., Herrera-Ruiz M., Estrada-Soto S., Aguirre-Crespo F., Vázquez-Navarrete L., León-Rivera I.
Publicada:
1 ene 2007
Resumen:
Seven new tetrasaccharide glycosides, tyrianthins 1-7 (1-7), along with six known glycolipids were isolated from the roots of Ipomoea tyrianthina, and their structures were elucidated by spectroscopic and chemical methods. The content of resin glycosides in samples collected in three different regions was analyzed and compared, and the results showed that the flowering or dry season did not have any effect on the chemical composition for the same locality, but the growing location itself did affect the chemical composition of resin glycosides. Intraperitoneal administration to mice of tyrianthin 6 (6) resulted in antidepressant activity. Tyrianthin 6 (6), scammonin 1 (8), and scammonin 2 (9) exhibited dose-dependent protective effects against pentylenetetrazole- induced seizures. Also, tyrianthin 6 (6) and scammonin 2 (9) produced relaxant effects on spontaneous contractions in the isolated rat ileum. © 2007 American Chemical Society and American Society of Pharmacognosy.
Filiaciones:
Mirón-López G.:
Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Ave. Universidad 1001, Col. Chamilpa, 62209 Cuernavaca, Morelos, Mexico
Herrera-Ruiz M.:
Centro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social, Argentina 1, Col. Centro, 62790 Xochitepec, Morelos, Mexico
Estrada-Soto S.:
Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Ave. Universidad 1001, Col. Chamilpa, 62209 Cuernavaca, Morelos, Mexico
Aguirre-Crespo F.:
Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Ave. Universidad 1001, Col. Chamilpa, 62209 Cuernavaca, Morelos, Mexico
Vázquez-Navarrete L.:
Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Ave. Universidad 1001, Col. Chamilpa, 62209 Cuernavaca, Morelos, Mexico
León-Rivera I.:
Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Ave. Universidad 1001, Col. Chamilpa, 62209 Cuernavaca, Morelos, Mexico
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