Neuromotor development in progeny of rats from lead-drinking mothers during pregnancy and lactation
Por:
Gijón E., Montoya M., Gallegos M.E., García X.
Publicada:
1 ene 2006
Resumen:
During the early stages of neuronal development and maturation of the central nervous system, exposure to low lead (Pb) levels produces lasting attenuation of memory and learning. Lead-related locomotor activity studies, one of the aspects most studied, have provided contradictory results; hyperactivity, hypoactivity, or no changes at all in locomotor activity. This study was designed to determine whether chronic Pb-exposure affects motor activity and coordination of motor reflexes in pups, using surface righting, negative geotaxis, and swimming tests. Wistar rats were exposed maternally and postnatally to lead acetate (1 mg/ml) in their drinking water. Since postnatal day 1 the Pb group developed the surface righting response in less time than the control group. The Pb group showed a delay of 2 days in developing the negative geotaxis test. In the swimming test, both groups presented the same sequence of maturation, except that the control group showed a delay of several days. Pb did not influence the age at which swimming began, but modified the rate at which the maturation pattern progresses. The faster response in surface righting reflex could be interpreted as hyperactivity. Lead intoxication in rats during maternally and postnatally period, induced transient dysfunction in motor skills.
Filiaciones:
Gijón E.:
Department of Physiology, School of Medicine, Universidad Nacional Autónoma de México, DF México, Mexico
Montoya M.:
Department of Physiology, School of Medicine, Universidad Nacional Autónoma de México, DF México, Mexico
Gallegos M.E.:
Department of Physiology, School of Medicine, Universidad Nacional Autónoma de México, DF México, Mexico
García X.:
Department of Physiology, School of Medicine, Universidad Nacional Autónoma de México, DF México, Mexico
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