Effect of chronic administration of an extract of Thevetia peruviana seed on a model of experimental obesity
Por:
Chávez C.A.G., Enríquez M.E.M., Sepúlveda A.E.C.
Publicada:
1 ene 2006
Resumen:
Obesity is a world-wide public health problem that is particularly dramatic in the United States. In recent years in Mexico, the Thevetia peruviana (Tp) seed has been used to reduce body weight; the intake of this seed has however caused toxicity and death. Animal studies have demonstrated the effectiveness of Tp seed in reducing body weight, but with a high lethality. Of the dry extracts of Tp seed obtained with ethyl acetate or methanol and water, the ethyl acetate extract (EAE) didn't cause toxicity. Here we assessed the effects of EAE in a model of experimental obesity in the mouse. Both male and female obese and non-obese animals were used; EAE with (200 mg/kg, diluted in oil corn) or without dilution was administered orally for 30 days to female and male mice respectively. Body weight and intake of and food and water were registered daily. EAE administration significantly reduced (p<0.05) body weight in both male and female obese mice. Significant differences in the first week of treatment were seen in non-obese male mice only. Also we observed a significant diminution (p<0.05) in the intake of water and food in the obese animal groups compared to non-obese animals. We conclude that EAE reduces body weight without causing lethality. However, the animals displayed excessive CNS stimulation.
Filiaciones:
Chávez C.A.G.:
Department of Pharmacology, Faculty of Medicine, National University Autonomous of Mexico, P.O. Box 70297, Mexico, D.F. 04510, Mexico
Enríquez M.E.M.:
Department of Pharmacology, Faculty of Medicine, National University Autonomous of Mexico, P.O. Box 70297, Mexico, D.F. 04510, Mexico
Sepúlveda A.E.C.:
Department of Pharmacology, Faculty of Medicine, National University Autonomous of Mexico, P.O. Box 70297, Mexico, D.F. 04510, Mexico
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