Evaluation of the hypoglycemic effect of Cucurbita ficifolia Bouché (Cucurbitaceae) in different experimental models
Por:
Alarcon-Aguilar F.J., Hernandez-Galicia E., Campos-Sepulveda A.E., Xolalpa-Molina S., Rivas-Vilchis J.F., Vazquez-Carrillo L.I., Roman-Ramos R.
Publicada:
1 ene 2002
Resumen:
Acute hypoglycemic effects of freeze-dried juice of Cucurbita ficifolia Bouché (Cucurbitaceae) fruits were studied in healthy and alloxan-diabetic mice. C. ficifolia fruit administered by intraperitoneal route produced, in a dose-dependent manner, a significant decrease of the glycemia in healthy mice. Although oral route of C. ficifolia fruit juice also caused significant reductions of blood glucose levels in healthy mice, the effect was minor. The juice administered by intraperitoneal route showed an acute hypoglycemic effect in alloxan-diabetic mice. In addition, daily oral administration of this preparation showed a highly significant reduction of the glycemia after 14 days of treatment. Freeze- dried juice caused acute toxicity when administered intraperitoneally, and also when it was administered daily by the oral route. © 2002 Elsevier Science Ireland Ltd. All rights reserved.
Filiaciones:
Alarcon-Aguilar F.J.:
División De Ciencias Biológicas Y De La Salud, Universidad Autónoma Metropolitana, Unidad Iztapalapa, Apdo. P. 55-535, 09340 Mexico, D.F., Mexico
Hernandez-Galicia E.:
División De Ciencias Biológicas Y De La Salud, Universidad Autónoma Metropolitana, Unidad Iztapalapa, Apdo. P. 55-535, 09340 Mexico, D.F., Mexico
Campos-Sepulveda A.E.:
Departamento De Farmacología, Ciudad Universitaria, UNAM, Mexico, D.F., Mexico
Xolalpa-Molina S.:
Herbario IMSS-M, Centro Médico Nacional Siglo XXI, Subjefatura De Investigación, Mexico, D.F., Mexico
Rivas-Vilchis J.F.:
División De Ciencias Biológicas Y De La Salud, Universidad Autónoma Metropolitana, Unidad Iztapalapa, Apdo. P. 55-535, 09340 Mexico, D.F., Mexico
Vazquez-Carrillo L.I.:
División De Ciencias Biológicas Y De La Salud, Universidad Autónoma Metropolitana, Unidad Iztapalapa, Apdo. P. 55-535, 09340 Mexico, D.F., Mexico
Roman-Ramos R.:
División De Ciencias Biológicas Y De La Salud, Universidad Autónoma Metropolitana, Unidad Iztapalapa, Apdo. P. 55-535, 09340 Mexico, D.F., Mexico
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