Monocyte cytokine and costimulatory molecule expression in patients infected with Leishmania mexicana
Por:
Carrada G., Cañeda C., Salaiza N., Delgado J., Ruiz A., Sanchez B., Gutiérrez-Kobeh L., Aguirre M., Becker I.
Publicada:
1 ene 2007
Resumen:
Leishmania mexicana causes localized and diffuse cutaneous leishmaniasis. Patients with localized cutaneous leishmaniasis (LCL) develop a benign disease, whereas patients with diffuse cutaneous leishmaniasis (DCL) suffer from a progressive disease associated with anergy of the cellular response towards Leishmania antigens. We evaluated the production of the interleukins (IL) IL-12, IL-15, IL-18 and tumour necrosis factor-a (TNF-a) and the expression of the costimulatory molecules CD40, B7-1 and B7-2 in monocytes from LCL and DCL patients, stimulated in vitro with Leishmania mexicana lipophosphoglycan (LPG) for 18 h. LCL monocytes significantly increased TNF-a, IL-15 and IL-18 production, and this increase was associated with reduced amounts of IL-12. DCL monocytes produced no IL-15 or IL-18 and showed a decreasing tendency of TNF-a and IL-12 production as the severity of the disease increased. No difference was observed in the expression of CD40 and B7-1 between both groups of patients, yet B7-2 expression was significantly augmented in DCL patients. It remains to be established if this elevated B7-2 expression in DCL patients is cause or consequence of the Th2-type immune response that characterizes these patients. These data suggest that the diminished ability of the monocytes from DCL patients to produce cell-activating innate proinflammatory cytokines when stimulated with LPG is a possible cause for disease progression. © 2006 The Authors.
Filiaciones:
Carrada G.:
Departamento de Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, México D.F., Mexico
Secretaría de Salud del Estado de Tabasco, Villahermosa, Tabasco, Mexico
Universidad Juárez Autónoma de Tabasco, Villahermosa, Tabasco, Mexico
Cañeda C.:
Departamento de Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, México D.F., Mexico
Salaiza N.:
Departamento de Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, México D.F., Mexico
Delgado J.:
Departamento de Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, México D.F., Mexico
Ruiz A.:
Departamento de Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, México D.F., Mexico
Sanchez B.:
Universidad Juárez Autónoma de Tabasco, Villahermosa, Tabasco, Mexico
Hospital Regional PEMEX-Villahermosa, Tabasco, Mexico
Gutiérrez-Kobeh L.:
Departamento de Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, México D.F., Mexico
Aguirre M.:
Departamento de Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, México D.F., Mexico
Becker I.:
Departamento de Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, México D.F., Mexico
Secretaría de Salud del Estado de Tabasco, Villahermosa, Tabasco, Mexico
Departamento de Medicina Experimental, Facultad de Medicina, UNAM, Dr Balmis 148, Colonia Doctores, 06726 México D.F., Mexico
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