Synthetic peptide vaccine against Taenia solium pig cysticercosis: Successful vaccination in a controlled field trial in rural Mexico
Por:
Huerta M., De Aluja A.S., Fragoso G., Toledo A., Villalobos N., Hernández M., Gevorkian G., Acero G., Díaz A., Alvarez I., Avila R., Beltrán C., Garcia G., Martinez J.J., Larralde C., Sciutto E.
Publicada:
1 ene 2001
Resumen:
Taenia solium cysticercosis seriously affects human health when localised in the central nervous system (CNS) and causes great economic loss in pig husbandry in rural areas of endemic countries. Increasing the resistance to the parasite in the obligatory host pig may help in curbing transmission. Three synthetic peptides based on protein sequences of the murine parasite Taenia crassiceps, which had previously been shown to induce protection in mice against homologous challenge, were tested as a vaccine against T. solium cysticercosis in pigs. Vaccinated and unvaccinated piglets (240 in all) were distributed in pairs among the peasants' households of two rural villages in Mexico in which 14% of the native pigs were cysticercotic. Ten to twelve months later, the effect of vaccination was evaluated at necropsy. Vaccination decreased the total number of T. solium cysticerci (98.7%) and reduced the prevalence (52.6%). The natural challenge conditions used in this field trial strengthen the likelihood of successful transmission control to both pig and human through a large-scale pig vaccination program. We believe this is a major contribution in anticysticercosis vaccine development as these rather simple yet protective peptides are potentially more cost-effective to produce and less variable in results than antigens that are more complex. © 2001 Elsevier Science Ltd. All rights reserved.
Filiaciones:
Huerta M.:
Facultad de Medicina, Benemérita Universidad Autónoma de Puebla, Puebla, Mexico
De Aluja A.S.:
Facultad De Medicina Veterinaria Y Zootecnia, Universidad Nacional Autónoma De México, México, DF 04510, Mexico
Fragoso G.:
Departmento De Immunolgía, Instituto De Investigaciones Biomédicas, Universidad Nacional Autónoma De México, AP 70228, México, DF 04510, Mexico
Toledo A.:
Departmento De Immunolgía, Instituto De Investigaciones Biomédicas, Universidad Nacional Autónoma De México, AP 70228, México, DF 04510, Mexico
Villalobos N.:
Facultad De Medicina Veterinaria Y Zootecnia, Universidad Nacional Autónoma De México, México, DF 04510, Mexico
Hernández M.:
Departmento De Immunolgía, Instituto De Investigaciones Biomédicas, Universidad Nacional Autónoma De México, AP 70228, México, DF 04510, Mexico
Gevorkian G.:
Departmento De Immunolgía, Instituto De Investigaciones Biomédicas, Universidad Nacional Autónoma De México, AP 70228, México, DF 04510, Mexico
Acero G.:
Departmento De Immunolgía, Instituto De Investigaciones Biomédicas, Universidad Nacional Autónoma De México, AP 70228, México, DF 04510, Mexico
Díaz A.:
Instituto Mexicano del Seguro Social, Benemérita Universidad Autónoma De Puebla, Puebla, Mexico
Alvarez I.:
Escuela De Medicina Veterinaria Y Zootecnia, Benemérita Universidad Autónoma De Puebla, Puebla, Mexico
Avila R.:
Escuela De Medicina Veterinaria Y Zootecnia, Benemérita Universidad Autónoma De Puebla, Puebla, Mexico
Beltrán C.:
Departmento De Immunolgía, Instituto De Investigaciones Biomédicas, Universidad Nacional Autónoma De México, AP 70228, México, DF 04510, Mexico
Garcia G.:
Departmento De Immunolgía, Instituto De Investigaciones Biomédicas, Universidad Nacional Autónoma De México, AP 70228, México, DF 04510, Mexico
Martinez J.J.:
Facultad De Medicina Veterinaria Y Zootecnia, Universidad Nacional Autónoma De México, México, DF 04510, Mexico
Larralde C.:
Departmento De Immunolgía, Instituto De Investigaciones Biomédicas, Universidad Nacional Autónoma De México, AP 70228, México, DF 04510, Mexico
Sciutto E.:
Departmento De Immunolgía, Instituto De Investigaciones Biomédicas, Universidad Nacional Autónoma De México, AP 70228, México, DF 04510, Mexico
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