New phenylethanoids from Buddleja cordata subsp. cordata
Por:
Acevedo L., Martínez E., Castañeda P., Franzblau S., Timmermann B.N., Linares E., Bye R., Mata R.
Publicada:
1 ene 2000
Resumen:
Bioassay-guided fractionation of a crude extract of the stem bark of Buddleja cordata subsp. cordata with significant antimycobacterial activity led to the isolation of a mixture composed by ten new long-chain esters of 2[4'-hydroxyphenyl]-ethanol (1-10), along with the lichen metabolites methyl ?-orcinolcarboxylate (11) and ?-orcinolcarboxylate (12). Extensive HPLC allowed the separation of the major components of the mixture, which were characterized by spectral means as 2[4'-hydroxyphenyl]-ethyl stearate (3), 2[4'-hydroxyphenyl]-ethyl behenate (6), and 2[4'-hydroxyphenyl]-ethyl lignocerate (8). The minor esters were identified as 2[4'-hydroxyphenyl]- ethyl palmitate (1), 2[4'-hydroxyphenyl]-ethyl heptadecanoate (2), 2[4'- hydroxyphenyl]-ethyl nonadecanoate (4), 2[4'-hydroxyphenyl]-ethyl arachidate (5), 2[4'-hydroxyphenyl]-ethyl tricosanoate (7), 2[4'-hydroxyphenyl]-ethyl pentacosanoate (9), and 2[4'-hydroxyphenyl]-ethyl hexacosanoate (10) by GC-MS analysis of the methyl esters derivatives of the fatty acids obtained by alkaline hydrolysis of the mixture. Compound 8 exhibited moderate antibacterial activity against Mycobacterium tuberculosis (MIC = 64 ?g/ml).
Filiaciones:
Acevedo L.:
Departamento de Farmacia, Facultad de Quimica, Univ. Nac. Autónoma de Mexico, D.F., Mexico, Mexico
Martínez E.:
Departamento de Farmacia, Facultad de Quimica, Univ. Nac. Autónoma de Mexico, D.F., Mexico, Mexico
Castañeda P.:
Departamento de Farmacia, Facultad de Quimica, Univ. Nac. Autónoma de Mexico, D.F., Mexico, Mexico
Franzblau S.:
G. W. L. Hansen's Disease Center, Baton Rouge, LA, United States
Timmermann B.N.:
Dept. of Pharmacol. and Toxicology, College of Pharmacy, University of Arizone, Tucson, AZ, United States
Linares E.:
Instituto de Biologia, Univ. Nac. Autónoma de Mexico, D.F., Mexico, Mexico
Bye R.:
Instituto de Biologia, Univ. Nac. Autónoma de Mexico, D.F., Mexico, Mexico
Mata R.:
Departamento de Farmacia, Facultad de Quimica, Univ. Nac. Autónoma de Mexico, D.F., Mexico, Mexico
Facultad de Química, Univ. Nac. Autonoma de México, Coyoacan 04510 México D.F., Mexico
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