Binding and activation of human plasminogen by Mycobacterium tuberculosis
Por:
Monroy V., Amador A., Ruiz B., Espinoza-Cueto P., Xolalpa W., Mancilla R., Espitia C.
Publicada:
1 ene 2000
Resumen:
The first evidence of the interaction of Mycobacterium tuberculosis with the plasminogen system is herein reported. By FACScan analysis and affinity blotting, lysine-dependent binding of plasminogen to M. tuberculosis was demonstrated. The binding molecules were 30-, 60-, and 66-kDa proteins present in cell wall and soluble protein extracts. The activation of plasminogen, which occurred only in presence of fibrin and was not inhibited by the host serpin, ?2-antiplasmin, was also demonstrated.
Filiaciones:
Monroy V.:
Depto. de Biología Molecular, Inst. de Invest. Biomédicas, Univ. Nac. Auton. de México, C.P. 04510 Mexico City D.F., Mexico
Amador A.:
Departamento de Inmunología, Inst. de Invest. Biomédicas, Univ. Nac. Auton. de México, C.P. 04510 Mexico City D.F, Mexico
Ruiz B.:
Depto. de Biología Molecular, Inst. de Invest. Biomédicas, Univ. Nac. Auton. de México, C.P. 04510 Mexico City D.F., Mexico
Espinoza-Cueto P.:
Departamento de Inmunología, Inst. de Invest. Biomédicas, Univ. Nac. Auton. de México, C.P. 04510 Mexico City D.F, Mexico
Xolalpa W.:
Depto. de Biología Molecular, Inst. de Invest. Biomédicas, Univ. Nac. Auton. de México, C.P. 04510 Mexico City D.F., Mexico
Mancilla R.:
Departamento de Inmunología, Inst. de Invest. Biomédicas, Univ. Nac. Auton. de México, C.P. 04510 Mexico City D.F, Mexico
Espitia C.:
Departamento de Inmunología, Inst. de Invest. Biomédicas, Univ. Nac. Auton. de México, C.P. 04510 Mexico City D.F, Mexico
Inst. de Invest. Biomédicas, Departamento de Inmunología, Apartado Postal 70-228, 04510 D.F. Mexico City D.F., Mexico
All Open Access, Bronze
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