The genome project of Taenia solium
Por:
Aguilar-Díaz H., Bobes R.J., Carrero J.C., Camacho-Carranza R., Cervantes C., Cevallos M.A., Dávila G., Rodríguez-Dorantes M., Escobedo G., Fernández J.L., Fragoso G., Gaytán P., Garciarubio A., González V.M., González L., José M.V., Jiménez L., Laclette J.P., Landa A., Larralde C., Morales-Montor J., Morett E., Ostoa-Saloma P., Sciutto E., Santamaría R.I., Soberón X., De La Torre P., Valdés V., Yánez J.
Publicada:
1 ene 2006
Resumen:
We have constituted a consortium of key laboratories at the National Autonomous University of Mexico to carry out a genomic project for Taenia solium. This project will provide powerful resources for the study of taeniasis/cysticercosis, and, in conjunction with the Echinococcus granulosus and Echinococcus multilocularis genome project of expressed sequence tags (ESTs), will mark the advent of genomics for cestode parasites. Our project is planned in two consecutive stages. The first stage is being carried out to determine some basic parameters of the T. solium genome. Afterwards, we will evaluate the best strategy for the second stage, a full blown genome project. We have estimated the T. solium genome size by two different approaches: cytofluorometry on isolated cyton nuclei, as well as a probabilistic calculation based on ~ 2000 sequenced genomic clones, ~3 000 ESTs, resulting in size estimates of 270 and 251 Mb, respectively. In terms of sequencing, our goal for the first stage is to characterize several thousand EST's (from adult worm and cysticerci cDNA libraries) and genomic clones. Results obtained so far from about 16,000 sequenced ESTs from the adult stage, show that only about 40% of the T. solium coding sequences have a previously sequenced homologue. Many of the best hits are found with mammalian genes, especially with humans. However, 1.5% of the hits lack homologues in humans, making these genes immediate candidates for investigation on pharmaco-therapy, diagnostics and vaccination. Most T. solium ESTs are related to gene regulation, and signal transduction. Other important functions are housekeeping, metabolism, cell division, cytoskeleton, proteases, vacuolar transport, hormone response, and extracellular matrix activities. Preliminary results also suggest that the genome of T. solium is not highly repetitive. © 2005 Elsevier Ireland Ltd. All rights reserved.
Filiaciones:
Aguilar-Díaz H.:
Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico
Bobes R.J.:
Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico
Carrero J.C.:
Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico
Camacho-Carranza R.:
Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico
Cervantes C.:
Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico
Cevallos M.A.:
Centro de Ciencias Genómicas, Universidad Nacional Autónoma de México, Mexico
Dávila G.:
Centro de Ciencias Genómicas, Universidad Nacional Autónoma de México, Mexico
Rodríguez-Dorantes M.:
Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico
Escobedo G.:
Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico
Fernández J.L.:
Centro de Ciencias Genómicas, Universidad Nacional Autónoma de México, Mexico
Fragoso G.:
Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico
Gaytán P.:
Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Mexico
Garciarubio A.:
Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Mexico
González V.M.:
Centro de Ciencias Genómicas, Universidad Nacional Autónoma de México, Mexico
González L.:
Facultad de Ciencias, Universidad Nacional Autónoma de México, Mexico
José M.V.:
Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico
Jiménez L.:
Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico
Laclette J.P.:
Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico
Landa A.:
Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico
Larralde C.:
Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico
Morales-Montor J.:
Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico
Morett E.:
Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Mexico
Ostoa-Saloma P.:
Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico
Sciutto E.:
Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico
Santamaría R.I.:
Centro de Ciencias Genómicas, Universidad Nacional Autónoma de México, Mexico
Soberón X.:
Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Mexico
De La Torre P.:
Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico
Valdés V.:
Facultad de Ciencias, Universidad Nacional Autónoma de México, Mexico
Yánez J.:
Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Mexico
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