Effect of stress on the Schultz-Dale reaction in guinea pig aorta
Por:
García X., Martínez R.D., González Díaz V., Tenorio Flores C., Gijón E.
Publicada:
1 ene 1999
Resumen:
The smooth muscle of thoracic aorta from guinea pig sensitized with egg albumin (EA) produced an anaphylactic contraction when it was exposed to EA. Experiments were performed to evaluate stress effects on the anaphylactic contraction in guinea pig aortic dugs. Two types of stressors were used as immunosuppressor stimuli: physical restraint and shaking of the animals. Both stressors diminished the amplitude of the Schultz-Dale contraction in aortic rings from sensitized guinea pig. The shake stress stimulus interrupted several times during each session induced higher immunosuppression in animals in which the active sensitization and the stress sessions began the same day. Severe restraint stress, prior to active immunization, also suppressed significantly the anaphylactic response. The Schultz-Dale reaction in guinea pig aorta seems to be a valuable technique to study the stress effects on the anaphylactic response.
Filiaciones:
García X.:
Department of Physiology, School of Medicine, Univ. Nacional Autonoma de Mexico, Ap. P. 70-250, Ciudad Universitaria, Mexico City D.F.04510, Mexico
Martínez R.D.:
Department of Physiology, School of Medicine, Univ. Nacional Autonoma de Mexico, Ap. P. 70-250, Ciudad Universitaria, Mexico City D.F.04510, Mexico
Department of Experimental Medicine, School of Medicine, Univ. Nacional Autonoma de Mexico, Ap. P. 70-250, Ciudad Universitaria, Mexico City D.F.04510, Mexico
González Díaz V.:
Department of Physiology, School of Medicine, Univ. Nacional Autonoma de Mexico, Ap. P. 70-250, Ciudad Universitaria, Mexico City D.F.04510, Mexico
Tenorio Flores C.:
Department of Physiology, School of Medicine, Univ. Nacional Autonoma de Mexico, Ap. P. 70-250, Ciudad Universitaria, Mexico City D.F.04510, Mexico
Gijón E.:
Department of Physiology, School of Medicine, Univ. Nacional Autonoma de Mexico, Ap. P. 70-250, Ciudad Universitaria, Mexico City D.F.04510, Mexico
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