Ingestion of chilli pepper (Capsicum annuum) reduces salicylate bioavailability after oral aspirin administration in the rat
Por:
Cruz L., Castañeda-Hernández G., Navarrete A.
Publicada:
1 ene 1999
Resumen:
The bioavailabilities of aspirin (acetylsalicylic acid) and of salicylic acid were studied in male Wistar rats after acute and chronic administration of a Capsicum annuum extract, containing 100 mg of capsaicin per gram. With a single administration of 100 mg/kg of the extract, aspirin blood levels remained unchanged, but salicylic acid bioavailability was reduced in 44% compared with control animals. With a single administration of 300 mg/kg of the extract, aspirin blood levels were undetectable while salicylic acid bioavailability was reduced in 59%. Chronic administration once daily for 4 weeks of 100 and 300 mg/kg of the extract resulted in undetectable aspirin blood levels, while salicylic acid bioavailability was reduced in 63 and 76%, respectively, compared with controls. Results show that Capsicum ingestion reduces oral drag bioavailability, likely as a result of the gastrointestinal effects of capsaicin.
Filiaciones:
Cruz L.:
Área Farmacéutica, Fac. de Estud. Superiores Zaragoza, Univ. Nac. Auton. de Mexico, Av. Guelatao 66, Iztapalapa, México D.F. 09230, Mexico
Castañeda-Hernández G.:
Secc. de Terap. Exp., Depto. de Farmacol. y Toxicol., Ctro. de Invest. y de Estud. A., México D.F. 14000, Mexico
Navarrete A.:
Facultad de Química, Departamento de Farmacia, Univ. Nac. Auton. de Mexico, Coyoacan, Mexico D.F. 04510, Mexico
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