Vasorelaxant effect of Mexican medicinal plants on isolated rat aorta
Por:
Aguirre-Crespo F., Castillo-España P., Villalobos-Molina R., López-Guerrero J.J., Estrada-Soto S.
Publicada:
1 ene 2005
Resumen:
The vasorelaxant effect of methanol extracts (0.86-50 ?g/ml) of Iresine calea, Psyttacanthus calyculathus (DC.) G. Don, Laelia autumnalis (Lex.) Lindley, Brickellia cavanillesii (Cass.) Gray, and Lepechinia caulescens (Ortega) Epling, plant species used in Mexican folk medicine for the treatment of hypertension and related diseases, were evaluated in isolated rat aortic rings. The extracts of I. calea and P. calyculathus did not show a vasorelaxant activity on norepinephrine-evoked contraction (NE, 1 × 10-7.5 M) in endothelium-intact (+E) and endothelium-denuded (-E) rat aorta rings. On the other hand, L. autumnalis and B. cavanillesii induced a concentration- dependent and endothelium-independent relaxation on rat aorta. However, the methanol extract of L. caulescens produced a significant vasodilator effect in a concentration-dependent and endothelium-dependent manner. In order to determine the mode of the vasorelaxant action evoked by L. caulescens, the extract was evaluated in the presence of L-NAME (inhibitor of nitric oxide synthase at 1 × 10-4 M) and indomethacin (inhibitor of cyclooxygenases at 1 × 10-5 M). Relaxation was blocked by L-NAME, indicating the extract vasodilating properties are endothelium mediated due to liberation of nitric oxide. © 2005 Taylor & Francis Ltd.
Filiaciones:
Aguirre-Crespo F.:
Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos, Mexico
Castillo-España P.:
Centro de Investigación en Biotecnología, Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos, Mexico
Villalobos-Molina R.:
Departamento de Farmacobiología, Centro de Investigación y de Estudios Avanzados Sede Sur, México, D.F., Mexico
Unidad de Biomedicina, Facultad de Estudios Superiores-Iztacala, Universidad Nacional Autónoma de México, Tlalnepantla, Mexico
López-Guerrero J.J.:
Departamento de Farmacobiología, Centro de Investigación y de Estudios Avanzados Sede Sur, México, D.F., Mexico
Estrada-Soto S.:
Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos, Mexico
Laboratorio L-12 de Farmacognosia y Química de Productos Naturales, Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Colonia Chamilpa, 62210, Cuernavaca, Mexico
All Open Access; Bronze
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