Evidence of non-genomic effect of a 17ß-diamino estrogen, an estradiol derivative, on motor activity in rodents
Por:
Lemini C., Rubio-Póo C., Silva G., Zarco de Coronado I.
Publicada:
1 ene 1998
Resumen:
Experimental and clinical studies have indicated that steroids can affect motor and cognitive performance by their action on the dopaminergic systems of the brain, mediated by genomic and non-genomic effects. 17?-(N,N-dietilendiamine)-1,3,5(10)estratrien-3-ol dihydrochloride (DED) and 17?-(N,N-diethylaminoethyl)-amino-5 ?-androstan-3?-ol dihydrochloride (DAD) were evaluated for their effect on motor activity in CD 1 mice and in normal and hyperactive Wistar rats induced by prenatal capsaicin treatment. Experimental groups were injected intraperitoneally (ip) with DED (1 mg/100 g), DAD (1 mg/100 g), EDTA1 (ethylene diamino tetra acetic acid, 1 mg/100 g), or EDTA2 (2 mg/100 g), and a control group which received saline solution (SS). Motor activity was evaluated 5 min after the injection. DED inhibited locomotion in both mice and rats. DAD did not produce any changes in motor activity, showing the importance of the estrogen in producing these changes in behaviour. The effect on motion produced by DED in the animals cannot be explained by its quelant properties, since administration to mice at equivalent or higher doses of EDTA did not produce significant changes in motor activity. The rapid onset, and short-term effect of DED indicates that the depression of motor activity by DED is probably mediated by interactions of the steroid with membrane receptors, a non-genomic effect.
Filiaciones:
Departamento de Farmacologia, Facultad de Medicina, Ciudad Universitaria, Apartado Postal 70-492, Mexico City 04511, Mexico
Departamento de Farmacologia, Facultad de Medicina, Ciudad Universitaria CP04510, Apartado Postal 70-297, Mexico City, Mexico
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