Estrogenic effects of the synthetic aminoestrogen 17ß-(5-hydroxy- 1pentylamino)- 1,3,5(10)-estratrien-3-ol (pentolame)
Por:
Lemus A.E., Jaimez R., Lemini C., Menjivar M., Silva G., Rubio-Poo C., Valenzuela F., Larrea F.
Publicada:
1 ene 1998
Resumen:
In this study, we investigated the effects of pentolame, a 17?- aminoestrogen derivative, upon coagulation, serum LH, pituitary progestin receptors, uterine weight, and endometrium morphological changes in the castrated female rat. Groups of animals were subcutaneously (s.c.) injected with either estradiol (E2) (0.1 up to 1000 ?g/animal), pentolame (1 up to 1000 ?g/animal), or the vehicle alone daily for 5 consecutive days starting 2 weeks following ovariectomy. Administration of pentolame (10 to 1000 ?g/animal) increased significantly (p < 0.05) the blood clotting time when compared with that obtained in the group of control animals (EC50 582 ?g). Pentolame (500 and 1000 ?g/rat for 5 days) caused a significant inhibition (p < 0.01) of serum LH levels (IC50 860 ?g), which remained suppressed until Day 5 post last injection. In addition, treatment with pentolame was able to restore in the castrated female rat the presence of specific estrogen-dependent progestin binding sites at the anterior pituitary level. The affinity constants and the number of binding sites of pentolame-induced progestin receptors were similar to those obtained with estradiol at equipotent doses (860 ?g vs. 1 ?g/animal, respectively). Administration of the 17?-aminoestrogen derivative resulted in a significant increase in uterine weight (EC50 420 ?g) and endometrial characteristics were indistinguishable from those observed in the group of rats treated with E2.
Filiaciones:
Departments of Reproductive Biology, UAM-Iztapalapa, Univ. Nac. Auton. M., Mexico City, Mexico
Department of Pharmacology, Sch. Med., Univ. Nac. Auton. de Mex., Mexico City, Mexico
Inst. Nac. la Nutr. Salvador Zubiran, Univ. Nac. Auton. de México, Mexico City, Mexico
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