Smooth muscle relaxing flavonoids and terpenoids from Conyza filaginoides
Por:
Mata R., Rojas A., Acevedo L., Estrada S., Calzada F., Rojas I., Bye R., Linares E.
Publicada:
1 ene 1997
Resumen:
Activity-guided fractionation of the smooth muscle relaxing, chloroform-methanol (1:1) extract of Conyza filaginoides (D.C.) Hieron (Asteraceae) led to the isolation of three flavonoids (quercetin 3-glucoside, rutin, and pinostrobin), one sterol (?-spinasterol), a sesquiterpenoid (?-caryophyllene 4,5-?-oxide), and two triterpenoids (erythrodiol and 3-?-tridecanoyloxy-28-hydroxyolean-12-ene). 3-?-Tridecanoyloxy-28-hydroxy-olean-12-ene is a new naturally occurring terpenoid. All the isolated compounds induced a concentration-dependent inhibition of the spontaneous contractions of rat ileum. The spasmolytic activity exhibited by the extract and active principles tends to support the traditional use of C. filaginoides as an antispasmodic agent.
Filiaciones:
Mata R.:
Departamento de Farmacia, Fac. Quim. U. Invest. Plantas M., Univ. Nac. Auton. de México, Coyoacan 04510, Mexico D.F., Mexico
Rojas A.:
Facultad de Química, Univ. Auton. de Querétaro, Centro Universitario 7610, Querétaro, Mexico
Acevedo L.:
Departamento de Farmacia, Fac. Quim. U. Invest. Plantas M., Univ. Nac. Auton. de México, Coyoacan 04510, Mexico D.F., Mexico
Estrada S.:
Departamento de Farmacia, Fac. Quim. U. Invest. Plantas M., Univ. Nac. Auton. de México, Coyoacan 04510, Mexico D.F., Mexico
Calzada F.:
U. Invest. Medica Farmacol. Prod. N., Hosp. Pediat. Ctro. Medico Nac. S., IMSS, México D.F., Mexico
Rojas I.:
Facultad de Química, Univ. Auton. de Querétaro, Centro Universitario 7610, Querétaro, Mexico
Bye R.:
Jardín Botánico, Instituto de Biología, Univ. Nac. Auton. de México, Coyoacan 04510, Mexico D.F., Mexico
Linares E.:
Jardín Botánico, Instituto de Biología, Univ. Nac. Auton. de México, Coyoacan 04510, Mexico D.F., Mexico
|