Amaranthus leucocarpus lectin recognizes human naive T cell subpopulations
Por:
Lascurain R., Porras F., Báez R., Chávez R., Martínez-Cairo S., Alvarez G., Zenteno E.
Publicada:
1 ene 1997
Resumen:
Amaranthus leucocarpus lectin (ALL) is specific for GaINAc residue found in the inner core of Gal?1,3GalNAc?1,O-Ser/Thr disaccharide (T-antigen) or GalNAc?1,O-Ser/Thr (T(n)-antigen). Flow cytometric analysis using fluorescein-labeled lectin and monoclonal antibodies against human cell surface markers indicated that 5.7% of mononuclear cells from human healthy donors are recognized by ALL. These cells have the phenotype CD2 +CD4 +CD19 - and most of the lymphocytes recognized are also CD27 +, CD45RA + and CD43 +. ALL possesses mitogenic activity on lymphocytes after neuraminidase treatment. Our results indicate that the receptors recognized by ALL could be considered surface markers for naive human T lymphocyte subsets.
Filiaciones:
Lascurain R.:
Departamento de Bioquímica, Inst. Nac. de Enferm. Respiratorias, Secretaría de Salud, Calzada de Tlalpan 4502, 14080, México, Mexico
Porras F.:
Centro de Investigaciones de Oriente, IMSS, Puebla 02300 México, Mexico
Báez R.:
Departamento de Bioquímica, Inst. Nac. de Enferm. Respiratorias, Secretaría de Salud, Calzada de Tlalpan 4502, 14080, México, Mexico
Chávez R.:
Departamento de Bioquímica, Inst. Nac. de Enferm. Respiratorias, Secretaría de Salud, Calzada de Tlalpan 4502, 14080, México, Mexico
Martínez-Cairo S.:
Unidad de Investigación, Ctro. Médico Nac. Siglo XXI, IMSS, México, Mexico
Alvarez G.:
Laboratorio de Immunologia, Departamento de Bioquímica, Univ. Nac. Auton. de México, 04510 México, Mexico
Zenteno E.:
Laboratorio de Immunologia, Departamento de Bioquímica, Univ. Nac. Auton. de México, 04510 México, Mexico
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