Smooth muscle relaxing compounds from Dodonaea viscosa
Por:
Rojas A., Cruz S., Ponce-Monter H., Mata R.
Publicada:
1 ene 1996
Resumen:
Bioassay-directed fractionation of the chloroform-methanol (1:1) extract of Dodonaea viscosa (L.) Jacq. (Sapindaceae) resulted in the isolation of four active spasmolytic principles: sakuranetin (1), 6-hydroxykaempferyl 3,7-dimethyl ether (2) hautriwaic acid (3), and ent-15,16-epoxy-9?H-labda-13(16)14-diene-3?,8?-diol (4). All the isolated compounds elicited a concentration-dependent inhibition of the spontaneous and electrically-induced contractions of guinea-pig ileum. Sakuranetin and the ent-labdane inhibited the ileum contractions evoked by acetylcholine (Ach), histamine, and barium chloride. In addition, both substances were capable of relaxing contractions of rat uterus induced by Ca2+ in K+-depolarizing solution, displacing to the right the concentration-response curves to Ca2+. These results suggest that sakuranetin and ent-15,16-epoxy-9?H-labda-13(16)14-diene-3?,8?-diol produce an interference with calcium metabolism in smooth muscle cells. The spasmolytic activity exhibited by the active principles from D. viscosa, provides the pharmacological basis for the traditional use of the plant as an antispasmodic agent.
Filiaciones:
Rojas A.:
Departamento de Farmacia, Facultad de Quimica, Univ. Nac. Auton. de México, Coyoacan 04510, Mexico D.F., Mexico
Facultad de Química, Univ. Auton. de Querétaro, Centro Universitario, 76010, Querétaro, Mexico
Cruz S.:
Departamento de Farmacología, Secc. de Terap. Experimental, CINVESTAV, 1400, México D.F., Mexico
Ponce-Monter H.:
U. de Invest. Medica en Farmacol., Ctro. Médico Nac. Siglo XXI, I.M.S.S., 03020, México, D.F., Mexico
Mata R.:
Departamento de Farmacia, Facultad de Quimica, Univ. Nac. Auton. de México, Coyoacan 04510, Mexico D.F., Mexico
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