Effects of GABAB receptor antagonists on two models of focal epileptogenesis
Por:
Brailowsky S., Montiel T., Meneses S., Di Scala G.
Publicada:
1 ene 1995
Resumen:
The acute effects of two GABA B receptor antagonists (phaclofen and CGP-35348) were studied in two types of epileptogenic activity: that produced by intracortical injections of baclofen and that appearing after withdrawal of chronic intracerebral GABA infusion (the GABA-withdrawal syndrome, GWS). Intracortical baclofen induced two types of electrographic paroxysmal discharges: one consisting of single spike-and-wave (pattern 1) and another of poly spike-and-wave patterns (pattern II). Both patterns showed similar latencies and temporal evolution of spike frequency discharges. Phaclofen, applied directly into the baclofen-induced epileptogenic focus, suppressed pattern 11 but was ineffective in modifying both pattern I and the GWS. CGP-35348, administered systemically, inhibited both patterns I and II. Intracortical microinjection of baclofen or phaclofen in rats showing a GWS had no effect, nor the systemically given CGP 35348. These results indicate a differential participation of GABAB receptors in GABA-related epileptic syndromes of cortical origin. © 1995 Elsevier Science B.V. All rights resreved.
Filiaciones:
Instituto de Fisiología Celular, Departamento de Neurociencias, Universidad Nacional Autónoma de México, Apartado Postal 70-253, México, 04510 D.F, Mexico
LNCC, Centre de Neurochimie, C.NR.S. - INSERM, Strasbourg, 67084, France
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