Effect of lectins on mouse peritoneal macrophage phagocytic activity
Por:
Maldonado G., Porras F., Fernández L., Vázquez L., Zenteno E.
Publicada:
1 ene 1994
Resumen:
We studied the in vitro ability of lectin-treated murine peritoneal macrophages to attach and phagocytize particulate antigens. Glucose and mannose specific lectins such as Con-A and lentil lectin, as well as complex lactosamine residues specific lectins, such as Phaseolus vulgaris var. cacahuate and Phaseolus coccineus var. alubia, increased the macrophage phagocytic activity towards heterologous erythrocytes, whereas peanut agglutinin, a galactose-specific lectin, diminished the macrophage phagocytic activity. These results suggest that a galactose-N-acetyl-D galactosamine-containing structure could participate as negative modulator of the phagocytic activity. © 1994 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
Filiaciones:
Maldonado G.:
Depto. Bioquímica, Facultad de Medicina, U.N.A.M., Ap. Postal, 70-159, 04510, DF, Mexico
Porras F.:
Depto. Bioquímica, Facultad de Medicina, U.N.A.M., Ap. Postal, 70-159, 04510, DF, Mexico
Fernández L.:
Depto. Bioquímica, Facultad de Medicina, U.N.A.M., Ap. Postal, 70-159, 04510, DF, Mexico
Vázquez L.:
Centro de Investigaciones Biológicas, Universidad Autónoma del Estado de Morelos, Cuernavaca Mor, Mexico
Zenteno E.:
Depto. Bioquímica, Facultad de Medicina, U.N.A.M., Ap. Postal, 70-159, 04510, DF, Mexico
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