Pyroglutamyl peptidase II activity is not in the processes of bulbospinal TRHergic neurons
Por:
Joseph-Bravo P., Fresán M.E., Cisneros M., Vargas M.A., Charli J.-L.
Publicada:
1 ene 1994
Resumen:
Pyroglutamyl peptidase II (PPII) is a neuronal ectoenzyme involved in released thyrotropin-releasing hormone (TRH) inactivation. In an attempt to define if it is present in the pre or postsynaptic membrane, we induced neuronal degeneration of serotonin-TRHergic cells that project from raphe nuclei to the spinal cord. 2-4 weeks after intracisternal injection of 5,7-dihydroxytryptamine, TRH levels decreased over 70% in the cervical, thoracic or lumbar regions of spinal cord. In contrast, no change of PPII activity was observed. Longer times after injection (6-8 weeks), a 59-66% increase in activity was detected in the lumbar region. These data suggest that PPII is not localized in these TRHergic neurons but probably in the target cells. © 1994.
Filiaciones:
Joseph-Bravo P.:
Instituto de Biotecnologia, Universidad Nacional Autónoma de México, AP 510-3, Mor, Cuernavaca, México 62271, Mexico
Fresán M.E.:
Instituto de Biotecnologia, Universidad Nacional Autónoma de México, AP 510-3, Mor, Cuernavaca, México 62271, Mexico
Cisneros M.:
Instituto de Biotecnologia, Universidad Nacional Autónoma de México, AP 510-3, Mor, Cuernavaca, México 62271, Mexico
Vargas M.A.:
Instituto de Biotecnologia, Universidad Nacional Autónoma de México, AP 510-3, Mor, Cuernavaca, México 62271, Mexico
Charli J.-L.:
Instituto de Biotecnologia, Universidad Nacional Autónoma de México, AP 510-3, Mor, Cuernavaca, México 62271, Mexico
|