Effects of 1,5 benzodiazepine beta lactam on sleep [Efecto de una beta lactama de 1.5 benzodiazepina sobre el sueño.]
Por:
Ayala-Guerrero F., Vargas-Reyna L., Taboada J., Martinez R., Cortes E.
Publicada:
1 ene 1993
Resumen:
Various substances have been used as sleep inductors, but their use has declined, due to their undesirable side effects, and they have been replaced mainly by benzodiazepines. There currently exists a great variety of benzodiazepines with an increasing, clinical use, although they also present certain disadvantages. The effect on sleep of the intraperitoneal administration (0.9 mg/kg) of 7-(p-cl-phenyl)-8-phenoxy-4,5-benzo-3-aza-2-none, was analysed in chronically implanted wistar rats. Results indicate that this substance decreases wakefulness and increases significantly slow-wave and paradoxical sleep. Latency of the first phase of paradoxical sleep show a tendency to increase. It is concluded that this substance has hypnogenic effects.
Filiaciones:
Ayala-Guerrero F.:
Instituto de Investigaciones Biomédicas e Instituto de Química, D. F., Ciudad Universitaria, Mexico
Vargas-Reyna L.:
Instituto de Investigaciones Biomédicas e Instituto de Química, D. F., Ciudad Universitaria, Mexico
Taboada J.:
Instituto de Investigaciones Biomédicas e Instituto de Química, D. F., Ciudad Universitaria, Mexico
Martinez R.:
Instituto de Investigaciones Biomédicas e Instituto de Química, D. F., Ciudad Universitaria, Mexico
Cortes E.:
Instituto de Investigaciones Biomédicas e Instituto de Química, D. F., Ciudad Universitaria, Mexico
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