Anticoagulant and estrogenic effects of two new 17ß-aminoestrogens, butolame [17ß-(4-hydroxy-1-butylamino)-1, 3,5(10)-estratrien-3-ol] and pentolame [17ß-(5-hydroxy-1-pentylamino)-1, 3,5(10)-estratrien-3-ol]
Por:
Lemini C., Rubio-Póo C., Silva G., Garcia-Mondragon J., Zavala E., Mendoza-Patiño N., Castro D., Cruz-Almanza R., Mandoki J.J.
Publicada:
1 ene 1993
Resumen:
The syntheses and characterizations of two new 17?-aminoestrogens, butolame [17?-(4-hydroxy-1-butylamino)-1, 3,5(10)-estratrien-3-ol] and pentolame [17?-(5-hydroxy-1-pentylamino)-1,3,5(10)-estratrien-3-ol], are presented. Both compounds, when administered in single subcutaneous injections to male mice and rats, produce dose-dependent increases in blood clotting times that may last several days. The estrogenic effects assessed by the vaginal cornification test are of relatively short duration. © 1993.
Filiaciones:
Departamento de Farmacología, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad Universitaria, Mexico
Facultad de Estudios Superiores Zaragoza, Universidad Nacional Autónoma de México, Ciudad Universitaria, Mexico
Instituto de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Mexico
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