Paramyosin is the Schistosoma mansoni (Trematoda) homologue of antigen B from Taenia solium (Cestoda)
Por:
Laclette J.P., Landa A., Arcos L., Willms K., Davis A.E., Shoemaker C.B.
Publicada:
1 ene 1991
Resumen:
Antigen B, a major antigen of the cestode parasite Taenia solium, has been purified and a portion of amino acid sequence obtained. Paramyosin of the trematode parasite Schistosoma mansoni, an immunogenic protein that has shown promise as a vaccine candidate, has several biochemical and immunological properties in common with antigen B. A full-length cDNA clone of S. mansoni paramyosin has been obtained and the predicted translation product contains a sequence that is highly homologous to the sequence obtained for antigen B. The predicted amino acid composition and isolectric point of paramyosin are nearly identical to those established for antigen B. Recombinant S. mansoni paramyosin, expressed in Escherichia coli as a fusion protein with ?-galactosidase, was recognized by antisera against T. solium antigen B. We conclude from these results that S. mansoni paramyosin and T. solium antigen B are hormologous proteins. Since S. mansoni paramyosin is thought to be a muscle protein and T. solium antigen B a secreted glycoprotein with anti-complement activity, this conclusion raises some interesting questions regarding the role of this class of proteins in the host-parasite relationship. © 1991.
Filiaciones:
Laclette J.P.:
Department of Immunology, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, A.P, 70228 Mexico City, Mexico
Landa A.:
Department of Immunology, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, A.P, 70228 Mexico City, Mexico
Arcos L.:
Department of Immunology, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, A.P, 70228 Mexico City, Mexico
Willms K.:
Department of Immunology, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, A.P, 70228 Mexico City, Mexico
Davis A.E.:
Division of Immunology, Children's Hospital, Boston, MA, United States
Shoemaker C.B.:
Department of Tropical Public Health, Harvard School of Public Health, Boston, MA, United States
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