Super-reactivity to amphetamine toxicity induced by schedule of reinforcement
Por:
Valencia-Flores M., Velázquez-Martínez D.N., Villarreal J.E.
Publicada:
1 ene 1990
Resumen:
The chronic exposure of rats to a schedule of operant water reinforcement coupled with chronically restricted access to water sensitized the animals to intermittent d-amphetamine injections (0.31-2.5 mg/kg with intervals of 12-23 days between any two injections) in such a way that this drug came to produce catastrophic losses of body weight (32.4% of control levels). In the sessions when d-amphetamine was administered, the rats were also given a total of 12 brief electric shocks. Loss of body weight was unaccompanied by parallel changes in operant behavior performance, or in food or water intake. Remarkably, in other studies with the same interventions (sham schedule sessions, water deprivation, and foot shocks), with the exception that reinforcers were never delivered, d-amphetamine did not produce catastrophic falls in body weight. This super-reactivity to d-amphetamine toxicity may be mediated by a possible stressor action of the schedule of reinforcement. Its mechanism might be analogous to the known sensitization produced by classical experimental stressor stimuli to the repeated administration of d-amphetamine. © 1990 Springer-Verlag.
Filiaciones:
Valencia-Flores M.:
Departamento de Psicofisiologia, Facultad de Psicologia and Departamento de Farmacologia, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico
Velázquez-Martínez D.N.:
Departamento de Psicofisiología, Facultad de Psicología, Universidad Nacional Autónoma de México, Mexico
Villarreal J.E.:
Departamento de Farmacología y Toxicología del Centro, de Investigación y Estudios Avanzados del Instituto Politécnico Nacional, Mexico
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