Estudio de la patogenicidad de conidiobolus Coronatus en animales de experimentacion
Por:
López-Martínez R., Toriello C., Mier T., Ximénez-García C., Martínez A., Fernándezdiez J.
Publicada:
1 ene 1978
Resumen:
The pathogenicity of a strain of Conidiobolus coronatus isolated from Aenolamia postica was investigated in 152 mice, 42 guinea pigs and 47 hamsters. Four routes of inoculation were used: intraperitoneal, subcutaneous, intratracheal and scarification in the oral mucosa. Each animal was inoculated 3 times at 3 week intervals. Animals were sacrificed at 1, 8, 15, 45 of 225 days after the first inoculation. Observations of macroscopic lesions (nodules, abscesses, adhesions, etc.) direct examinations, cultures and histopathological studies of different tissues were performed. The aforementioned lesions of tissue were the most frequently found and all of them were resolved by spontaneous cure. The animals inoculated intraperitoneally and subcutaneouslly presented the highest number of positive results. The histopathological features at the 1st and 8th days after inoculation showed an acute inflamatory infiltrate with well preserved fungus filaments; at the 15th day granulomas with giant cells were observed containing fragmented and disintegrated fungal hyphae; at the 45th and 225th days a fibrosis reaction was observed and no fungal filaments, could be found. In no animal was rhinoentomophthoromycosis never reproduced, and according to these results it is considered that either this strain is not a pathogen or its pathogenicity is very low. © 1978 Dr. W. Junk bv - Publishers.
Filiaciones:
López-Martínez R.:
Depto. de de Ecologia Humana, Facul 'tad de Medicina, U.N. A.M., México 20, D.F., Mexico
Toriello C.:
Depto. de de Ecologia Humana, Facul 'tad de Medicina, U.N. A.M., México 20, D.F., Mexico
Mier T.:
Depto. de de Ecologia Humana, Facul 'tad de Medicina, U.N. A.M., México 20, D.F., Mexico
Ximénez-García C.:
Depto. de de Ecologia Humana, Facul 'tad de Medicina, U.N. A.M., México 20, D.F., Mexico
Martínez A.:
Depto. de de Ecologia Humana, Facul 'tad de Medicina, U.N. A.M., México 20, D.F., Mexico
Fernándezdiez J.:
Depto. de de Ecologia Humana, Facul 'tad de Medicina, U.N. A.M., México 20, D.F., Mexico
C.M.N. Instituto Mexicano del Seguro Social, Servico de Patología. Hospital General, México 7, D.F., Mexico
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