Lactate and pyruvate utilization by the spermatozoa of infertile human males
Por:
Pedron N., Giner J., Hicks J.J.
Publicada:
1 ene 1978
Resumen:
In studying the metabolic pathway of lactate and pyruvate in human spermatozoa from fertile and infertile subjects, pyruvate 1-C14 and lactate 1-C14 were used as substrates in a radiorespirometry system. Spermatozoa from patients with 20±2.0/106 spz/ml and decreased motility (group B) showed a more active decarboxylation of both pyruvate 1-C14 and lactate 1-C14 with a higher production of lactate C14, oxaloacetate, citrate, and isocitrate than those from fertile normal subjects (group A). Spermatozoa from fertile patients with normal counts but low motility showed a similar rate of decarboxylation of pyruvate 1-C14 but a greater rate of decarboxylation of lactate 1-C14 than those from fertile subjects. The low utilization of pyruvate by the spermatozoa from group C infertile patients, with intermediate counts and motility could be explained by a metabolic failure similar to that produced by some inhibitors of the respiratory chain. The authors do not have an explanation for the metabolic behavior observed in spermatozoa from group B patients, and further research on this point is desirable.
Filiaciones:
Pedron N.:
Div. Biol. Reproducc., Dept. Invest. Med. Exp., Cent. Med. Nac., IMSS, Mexico City, Mexico
Giner J.:
Div. Biol. Reproducc., Dept. Invest. Med. Exp., Cent. Med. Nac., IMSS, Mexico City, Mexico
Hicks J.J.:
Div. Biol. Reproducc., Dept. Invest. Med. Exp., Cent. Med. Nac., IMSS, Mexico City, Mexico
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