Observations on the ultrastructure of lesions induced in human and guinea pig skin by C 1 esterase and polypeptide from hereditary angioneurotic edema (HANE) plasma
Por:
Willms K., Rosen F.S., Donaldson V.H.
Publicada:
1 ene 1975
Resumen:
Intradermally injected preparations of purified Cls? and polypeptide from plasma of persons with hereditary angioneurotic edema (HANE) induced venular lesions with ultrastructural changes of the endothelium similar to changes induced by histamine (1). Treatment of test animals with an antihistaminic did not block increased vascular permeability about injections of HANE polypeptide or bradykinin. Animals depleted of C3 demonstrated decreased change in vascular permeability about injections of Cls?, but responses to histamine, bradykinin and HANE polypeptide were not blocked. Patients with HANE excreted larger amounts of histamine in their urine than normals; this increase was most pronounced as an epidsode of edema was subsiding. © 1975.
Filiaciones:
Willms K.:
Department of Molecular Biology, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, 22 DF, Mexico, Mexico
Rosen F.S.:
Departments of Immunology, Children's Hospital Medical Center, Boston, MA 02115, United States
Donaldson V.H.:
Department of Pediatrics and Medicine, Children's Hospital Medical Center, Cincinnati, OH 45229, United States
the University of Cincinnati, Cincinnati, OH 45229, United States
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