Isolation and properties of two calcitonins from chicken ultimobranchial glands
Por:
Nieto A., Moya F., R-Candela J.L.
Publicada:
1 ene 1973
Resumen:
Calcitonin was extracted from the ultimobranchial gland of chicken and purified by gel filtration and ion exchange chromatography. Bioassays of the column effluents led to the detection of two forms of the hormone. One form, present in higher proportion, was shown to be homogeneous by several criteria. The amino acid composition of this component differs markedly from that of mammalian calcitonins but is close to that of salmon calcitonin. Its biological properties are also similar to those of the salmon hormone. Its mean specific biological activity is about 4500 Medical Research Council units per mg, the highest value reported for any calcitonin obtained so far. This unusual potency may be related to a higher stability of the hormone in the organism. © 1973.
Filiaciones:
Nieto A.:
Departamento de Biología Molecular, Instituto G. Marañón, C.S.I.C. Velázquez 144, Madrid 6 Spain
Moya F.:
Departamento de Biología Molecular, Instituto G. Marañón, C.S.I.C. Velázquez 144, Madrid 6 Spain
R-Candela J.L.:
Departamento de Biología Molecular, Instituto G. Marañón, C.S.I.C. Velázquez 144, Madrid 6 Spain
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