Macro- and micromechanical behaviors of poly(lactic acid)–hydroxyapatite electrospun composite scaffolds
Por:
Sanchez-Arevalo, F. M., Munoz-Ramirez, L. D., Alvarez-Camacho, M., Rivera-Torres, F., Maciel-Cerda, A., Montiel-Campos, R., Vera-Graziano, R.
Publicada:
1 mar 2017
Resumen:
It was demonstrated that the macro- and micromechanical behaviors of electrospun composite scaffolds based on PLA and HA can be simultaneously studied using 3D digital image correlation strain measurements coupled with an axial tensile test. It was proven that the addition of a small quantity (2%) of HA particles into PLA electrospun scaffolds decreased their mechanical properties by approximately 40 and 60% at the micro- and macroscales, respectively; nevertheless, when this amount was increased beyond 2% of HA, the composites recovered their stiffness, showing Young’s moduli ranging between 400 and 600 MPa. Hence, the mechanical responses of PLA–4% HA and PLA–6% HA electrospun scaffolds were conveniently enhanced with the addition of hydroxyapatite nanoparticles. The micromechanical measurements were able to capture the microstrain mechanism between electrospun nanofibers and the effect of HA nanoparticles on their mechanical response. This methodology could be a powerful tool for developing scaffolds for specific applications in tissue engineering. © 2016, Springer Science+Business Media New York.
Filiaciones:
Sanchez-Arevalo, F. M.:
Univ Nacl Autonoma Mexico, Inst Invest Mat, Apdo Postal 70-360,Cd Univ, Mexico City 04510, DF, Mexico
Munoz-Ramirez, L. D.:
Univ Nacl Autonoma Mexico, Inst Invest Mat, Apdo Postal 70-360,Cd Univ, Mexico City 04510, DF, Mexico
Alvarez-Camacho, M.:
Inst Nacl Rehabil, Lab Ingn Rehabil, Av Mexico Xochimilco 289, Mexico City 14389, DF, Mexico
Rivera-Torres, F.:
Univ Nacl Autonoma Mexico, Fac Quim, Lab Fis, Dept Fis & Quim Teor, Apdo Postal 70-360, Mexico City 04510, DF, Mexico
Maciel-Cerda, A.:
Univ Nacl Autonoma Mexico, Inst Invest Mat, Apdo Postal 70-360,Cd Univ, Mexico City 04510, DF, Mexico
Montiel-Campos, R.:
Univ Autonoma Metropolitana Iztapalapa, Dept Fis Av San Rafael Atlixco, Av San RafaelAtlixco 186 Col Vicentina, Mexico City 09340, DF, Mexico
Vera-Graziano, R.:
Univ Nacl Autonoma Mexico, Inst Invest Mat, Apdo Postal 70-360,Cd Univ, Mexico City 04510, DF, Mexico
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