Solution structure and antiparasitic activity of scorpine-like peptides from Hoffmannihadrurus gertschi
Por:
Flores-Solis, David, Toledano, Yanis, Rodriguez-Lima, Oscar, Cano-Sanchez, Patricia, Ernestina Ramirez-Cordero, Belen, Landa, Abraham, Rodriguez de la Vega, Ricardo C., del Rio-Portilla, Federico
Publicada:
1 jul 2016
Resumen:
Scorpine-like peptides are two domain peptides found in different
scorpion venoms displaying various antimicrobial, cytolytic, and
potassium channel-blocking activities. The relative contribution of each
domain to their different activities remains to be elucidated. Here, we
report the recombinant production, solution structure, and antiparasitic
activity of Hge36, first identified as a naturally occurring truncated
form of a Scorpine-like peptide from the venom of Hoffmannihadrurus
gertschi. We also show that removing the first four residues from Hge36
renders a molecule with enhanced potassium channel-blocking and
antiparasitic activities. Our results are important to rationalize the
structure-function relationships of a pharmacologically versatile
molecular scaffold.
Filiaciones:
Flores-Solis, David:
Univ Nacl Autonoma Mexico, Dept Quim Biomacromol, Inst Quim, Mexico City 04510, DF, Mexico
Toledano, Yanis:
Univ Nacl Autonoma Mexico, Dept Quim Biomacromol, Inst Quim, Mexico City 04510, DF, Mexico
Univ Nacl Autonoma Mexico, Dept Quim Inorgan & Nucl, Fac Quim, Mexico City, DF, Mexico
Rodriguez-Lima, Oscar:
Univ Nacl Autonoma Mexico, Dept Microbiol & Parasitol, Fac Med, Mexico City, DF, Mexico
Cano-Sanchez, Patricia:
Univ Nacl Autonoma Mexico, Dept Quim Biomacromol, Inst Quim, Mexico City 04510, DF, Mexico
Ernestina Ramirez-Cordero, Belen:
Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Div Neurociencias, Dept Neuropatol Mol, Mexico City, DF, Mexico
Landa, Abraham:
Univ Nacl Autonoma Mexico, Dept Microbiol & Parasitol, Fac Med, Mexico City, DF, Mexico
Rodriguez de la Vega, Ricardo C.:
Univ Paris Saclay, AgroParisTech, Univ Paris Sud, Ecol Systemat Evolut,CNRS,UMR8079, Orsay, France
del Rio-Portilla, Federico:
Univ Nacl Autonoma Mexico, Dept Quim Biomacromol, Inst Quim, Mexico City 04510, DF, Mexico
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