Microdomains Associated to Lipid Rafts
Por:
Pacheco, Jonathan, Ramirez-Jarquin, Josue O., Vaca, Luis
Publicada:
1 ene 2016
Resumen:
Store Operated Ca2+ Entry (SOCE), the main Ca2+ influx mechanism in
non-excitable cells, is implicated in the immune response and has been
reported to be affected in several pathologies including cancer. The
basic molecular constituents of SOCE are Orai, the pore forming unit,
and STIM, a multidomain protein with at least two principal functions:
one is to sense the Ca2+ content inside the lumen of the endoplasmic
reticulum(ER) and the second is to activate Orai channels upon depletion
of the ER. The link between Ca2+ depletion inside the ER and Ca2+ influx
from extracellular media is through a direct association of STIM and
Orai, but for this to occur, both molecules have to interact and form
clusters where ER and plasma membrane (PM) are intimately apposed. In
recent years a great number of components have been identified as
participants in SOCE regulation, including regions of plasma membrane
enriched in cholesterol and sphingolipids, the so called lipid rafts,
which recruit a complex platform of specialized microdomains, which
cells use to regulate spatiotemporal Ca2+ signals.
Filiaciones:
Pacheco, Jonathan:
Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Ciudad Univ, Mexico City 04510, DF, Mexico
Ramirez-Jarquin, Josue O.:
Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Ciudad Univ, Mexico City 04510, DF, Mexico
Vaca, Luis:
Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Ciudad Univ, Mexico City 04510, DF, Mexico
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