Th1, Th2, Th17 and Treg levels in umbilical cord blood in preeclampsia
Por:
Vargas-Rojas, Maria I., Solleiro-Villavicencio, Helena, Soto-Vega, Elena
Publicada:
18 may 2016
Resumen:
Introduction: Preeclampsia is one of the major causes of maternal and
neonatal mortality. During pregnancy, the immune system must maintain
the tolerance to the fetus, thus changes in the cytokine balance may
result in a disturbed pregnancy. T helper cells play an important role
in modulation of the immune system and are involved in this cytokine
balance.
Objective: Many studies have been performed to study the T cell
composition in different compartments during pregnancy, although this is
the first study in which T cells are evaluated in umbilical cord blood.
Study design: Intracellular expression of INF-gamma, IL-17, IL-4 and
forkhead foxP3 in CD4+ T cells was evaluated in umbilical blood from
healthy pregnant and preeclamptic women using a flow cytometer.
Results: Th2 and Treg cells levels were significantly diminished in
preeclamptic compared to the healthy women, but no difference in Th1 and
Th17 levels were found between both groups.
Conclusions: Our data suggest that the cytokine balance is broken,
encouraging the development of an exacerbated inflammatory response. Our
results show that there is a shift, in the Th1/Th2, and the Th17/Treg
balance, favoring skewness towards a proinflammatory status in the
umbilical cord blood in preeclampsia.
Filiaciones:
Inst Nacl Enfermedades Resp Ismael Cosio Villegas, Lab Inflamac & Inmunoregulac, Mexico City, DF, Mexico
Univ Nacl Autonoma Mexico, Fac Med, Unidad Posgrado, Mexico City 04510, DF, Mexico
Univ Popular Autonoma Estado Puebla, Dept Ciencias Salud, 21 Sur 1103, Puebla 72410, Mexico
Nueva Esperanza AC, Lab Invest, Puebla, Mexico
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