Mushroom spine dynamics in medium spiny neurons of dorsal striatum associated with memory of moderate and intense training
Por:
Bello-Medina, Paola C., Flores, Gonzalo, Quirarte, Gina L., McGaugh, James L., Prado Alcala, Roberto A.
Publicada:
18 oct 2016
Categoría:
Multidisciplinary
Resumen:
A growing body of evidence indicates that treatments that typically
impair memory consolidation become ineffective when animals are given
intense training. This effect has been obtained by treatments
interfering with the neural activity of several brain structures,
including the dorsal striatum. The mechanisms that mediate this
phenomenon are unknown. One possibility is that intense training
promotes the transfer of information derived from the enhanced training
to a wider neuronal network. We now report that inhibitory avoidance
(IA) induces mushroom spinogenesis in the medium spiny neurons (MSNs) of
the dorsal striatum in rats, which is dependent upon the intensity of
the foot-shock used for training; that is, the effect is seen onlywhen
high-intensity foot-shock is used in training. We also found that the
relative density of thin spines was reduced. These changes were evident
at 6 h after training and persisted for at least 24 h afterward.
Importantly, foot-shock alone did not increase spinogenesis. Spine
density in MSNs in the accumbens was also increased, but the increase
did not correlate with the associative process involved in IA; rather,
it resulted from the administration of the aversive stimulation alone.
These findings suggest that mushroom spines of MSNs of the dorsal
striatum receive afferent information that is involved in the
integrative activity necessary for memory consolidation, and that
intense training facilitates transfer of information from the dorsal
striatum to other brain regions through augmented spinogenesis.
Filiaciones:
Univ Nacl Autonoma Mexico, Inst Neurobiol, Dept Neurobiol Conductual & Cognit, Queretaro 76230, Mexico
Benemerita Univ Autonoma Puebla, Inst Fisiol, Puebla 72570, Mexico
Univ Calif Irvine, Ctr Neurobiol Learning & Memory, Irvine, CA 92697 USA
Univ Calif Irvine, Dept Neurobiol & Behav, Irvine, CA 92697 USA
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