Effect of the aged garlic extract on cardiovascular function in metabolic syndrome rats
Por:
Perez-Torres, Israel, Carlos Torres-Narvaez, Juan, Pedraza-Chaverri, Jose, Esther Rubio-Ruiz, Maria, Diaz-Diaz, Eulises, del Valle-Mondragon, Leonardo, Martinez-Memije, Raul, Varela Lopez, Elvira, Guarner-Lans, Veronica
Publicada:
1 nov 2016
Resumen:
The antioxidant properties of aged garlic extract (AGE) on cardiovascular functioning (CF) in metabolic syndrome (MS) remains poorly studied. Here we study the AGE effects on CF in a rat model of MS. Control rats plus saline solution (C + SS), MS rats (30% sucrose in drinking water from weaning) plus saline solution (MS + SS), control rats receiving AGE (C + AGE 125 mg/Kg/12 h) and MS rats with AGE (MS + AGE) were studied. MS + SS had increased triglycerides, systolic blood pressure, insulin, leptin, HOMA index, and advanced glycation end products. AGE returned their levels to control values (p < 0.01). Cholesterol was decreased by AGE (p = 0.05). Glutathion and GPx activity were reduced in MS + SS rats and increased with AGE (p = 0.05). Lipid peroxidation was increased in MS + SS and AGE reduced it (p = 0.001). Vascular functioning was deteriorated by MS (increased vasocontraction and reduced vasodilation) and AGE improved it (p = 0.001). Coronary vascular resistance was increased in MS rats and AGE decreased it (p = 0.001). Cardiac performance was not modified by MS but AGE increased it. NO measured in the perfusate liquid from the heart and serum citrulline, nitrites/nitrates were decreased in MS and AGE increased them (p < 0.01). In conclusion, AGE reduces MS-induced cardiovascular risk, through its anti-oxidant properties. © 2016 by the authors; licensee MDPI, Basel, Switzerland.
Filiaciones:
Perez-Torres, Israel:
Inst Nacl Cardiol Ignacio Chavez, Dept Pathol, Juan Badiano 1,Secc 16, Mexico City 14080, DF, Mexico
Carlos Torres-Narvaez, Juan:
Inst Nacl Cardiol Ignacio Chavez, Dept Pharmacol, Juan Badiano 1,Secc 16, Mexico City 14080, DF, Mexico
Pedraza-Chaverri, Jose:
Univ Nacl Autonoma Mexico, Dept Biol, Fac Quim, Lab 209, Edificio B,Ciudad Univ, Mexico City 04510, DF, Mexico
Esther Rubio-Ruiz, Maria:
Inst Nacl Cardiol Ignacio Chavez, Dept Physiol, Juan Badiano 1,Secc 16, Mexico City 14080, DF, Mexico
Diaz-Diaz, Eulises:
Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Reprod Biol, Vasco de Quiroga 15,Secc 16, Mexico City 14000, DF, Mexico
del Valle-Mondragon, Leonardo:
Inst Nacl Cardiol Ignacio Chavez, Dept Pharmacol, Juan Badiano 1,Secc 16, Mexico City 14080, DF, Mexico
Martinez-Memije, Raul:
Inst Nacl Cardiol Ignacio Chavez, Electromech Instrumentat, Juan Badiano 1,Secc 16, Mexico City 14080, DF, Mexico
Varela Lopez, Elvira:
Inst Nacl Cardiol Ignacio Chavez, Dept Physiol, Juan Badiano 1,Secc 16, Mexico City 14080, DF, Mexico
Guarner-Lans, Veronica:
Inst Nacl Cardiol Ignacio Chavez, Dept Physiol, Juan Badiano 1,Secc 16, Mexico City 14080, DF, Mexico
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