Prolactin and Prolactin Receptor Expression in Cervical Intraepithelial Neoplasia and Cancer
Por:
Ascencio-Cedillo R., López-Pulido E.I., MunozValle, JF, Villegas-Sepúlveda N., Del Toro-Arreola S., Estrada-Chávez C., Daneri-Navarro A., Franco-Topete R., Pérez-Montiel D., García-Carrancá A., Pereira-Suárez A.L.
Publicada:
1 abr 2015
Resumen:
Prolactin receptor (PRLR) overexpression could play a role in
tumorigenesis. The aim of this study was to determine prolactin (PRL)
and PRLR expression in biopsies from patients with precursor lesions and
uterine cervical cancer. PRLR expression was analyzed in 63
paraffin-embedded biopsies of uterine cervical tissue. In total, eleven
low-grade squamous intraepithelial lesions (LSIL), 23 high-grade
squamous intraepithelial lesions (HSIL), 21 uterine cervical cancers
(UCC) and 8 normal epithelium (NE) were examined using immunoperoxidase
staining and Western blot analysis. Additionally, PRL expression was
identified in human cervical cancer serum and tissues. The PRLR
expression was found to be significantly increased in cervical cancer in
comparison with normal tissue and precursor lesions (P < 0.0003). The
presence of the long isoform of the PRLR was observed only in cervical
cancer tissues. Serum PRL levels were normal in all samples and local
prolactin expression was similar in precursor lesions and cervical
cancer by Western blot analysis. Our data suggest a possible role for
PRLR in the progression of cervical cancer.
Filiaciones:
Ascencio-Cedillo R.:
Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico
López-Pulido E.I.:
Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico
Villegas-Sepúlveda N.:
Departamento de Biomedicina Molecular, Centro de Investigación y de Estudios Avanzados-IPN, Unidad Zacatenco, Mexico City, DF 07360, Mexico
Del Toro-Arreola S.:
Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico
Estrada-Chávez C.:
Centro de Investigación y Asistencia en Tecnología y diseño del Estado de Jalisco A.C, Guadalajara, Jalisco 44270, Mexico
Daneri-Navarro A.:
Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico
Franco-Topete R.:
Departamento de Patología. Nuevo Hospital Civil de Guadalajara, Guadalajara, Jalisco, Mexico
Pérez-Montiel D.:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Dept Biol Mol & Biotecnol, Mexico City, DF, Mexico
García-Carrancá A.:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Dept Biol Mol & Biotecnol, Mexico City, DF, Mexico
Pereira-Suárez A.L.:
Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico
Laboratorio de Inmunología, Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra, Mojada # 950, Colonia Independencia, Guadalajara, Jalisco CP 44340, Mexico
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