The Role of Signaling Pathways in Cervical Cancer and Molecular Therapeutic Targets
Por:
Manzo-Merino, J, Contreras-Paredes, A, Vazquez-Ulloa, E, Rocha-Zavaleta, L, Fuentes-Gonzalez, AM, Lizano, M
Publicada:
1 oct 2014
Categoría:
Medicine (miscellaneous)
Resumen:
Cervical cancer is a public health issue in developing countries.
Although the Pap smear and colposcopy remain the major strategies for
detection, most cases are diagnosed in the late stages. Therefore, a
major concern has been to develop early diagnostic approaches and more
effective treatments. Molecular pathways that participate in cervical
malignant transformation have emerged as promising directed therapeutic
targets. In this review, we explore some of the major pathways
implicated in cervical cancer development, including RAF/MEK/ERK,
phosphatidylinositol-3 kinase (PI3K/AKT), Wnt/b-catenin, apoptosis and
coupled membrane receptor signaling. We focus on the role of these
pathways in cervical carcinogenesis, their alterations and the
consequences of these abnormalities. In addition, the most recent
preclinical and clinical data on the rationally designed target-based
agents that are currently being tested against elements of these
pathways are reviewed. (C) 2014 IMSS. Published by Elsevier Inc.
Filiaciones:
Manzo-Merino, J:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Inst Nacl Cancerol, Unidad Invest Biomed Canc, Mexico City 04510, DF, Mexico
Contreras-Paredes, A:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Inst Nacl Cancerol, Unidad Invest Biomed Canc, Mexico City 04510, DF, Mexico
Vazquez-Ulloa, E:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Inst Nacl Cancerol, Unidad Invest Biomed Canc, Mexico City 04510, DF, Mexico
Rocha-Zavaleta, L:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Dept Mol Biol & Biotechnol, Mexico City 04510, DF, Mexico
Fuentes-Gonzalez, AM:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Inst Nacl Cancerol, Unidad Invest Biomed Canc, Mexico City 04510, DF, Mexico
Lizano, M:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Inst Nacl Cancerol, Unidad Invest Biomed Canc, Mexico City 04510, DF, Mexico
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