The distribution of high-risk human papillomaviruses is different in young and old patients with cervical cancer
Por:
Guardado-Estrada M., Juárez-Torres E., Román-Bassaure E., Medina-Martinez I., Alfaro A., Benuto R.E., Dean M., Villegas-Sepulveda N., Berumen J.
Publicada:
8 oct 2014
Resumen:
Despite numerous human papillomavirus (HPV) frequency studies in women with cervical cancer (CC), little is known of HPV frequency trends according to patient age. In this work, we compare the mean age and frequency distribution by age of CC patients positive for different HPVs. This study included 462 CC patients. HPVs were detected by PCR and typed using DNA sequencing. A total of 456 patients (98.7%) were positive for HPV: 418 (90.5%) had single and 38 (8.2%) had double HPV infections. HPV16 (46.5%), HPV18 (10.4%), HPV45 (6.7%), and HPV31 (4.1%) were the most frequent viral types in singleinfected patients. The mean ages of single-infected patients with HPV16 (49.2±13.3), HPV18 (47.9±12.2), HPV45 (47.9±11.7), or HPV39 (42.6±8.9) were significantly lower than the mean ages of patients singly (53.9±12.7; p<0.001, t-test) or doubly (55.4±12.7; p<0.05, t-test) infected with the remaining HPVs. Three different trends were identified: one for HPV16, another for HPVs18/45/39, and a third for the rest of HPVs. The frequency trend of HPV16 shows two peaks. The first (63.2%) was found in the youngest women (=35 years), followed by a decreasing trend until the age of 55-60 years (31.1%). The second peak arose at 61-65 years (52.5%), followed by a decreasing trend. The trend for HPVs18/45/39 declined from the youngest (19.3%) to the oldest (>70 years; 12.8%) women. In contrast, the trend for the remaining HPVs increased from the youngest (15.8%) to the oldest (46.2%) women. Unlike other life-style factors, low-risk sexual behavior was associated with late onset of CC independent of low-oncogenic HPV types (p<0.05, Wald chi-square statistic). The data indicate that most CCs in young women depend on the presence of high-oncogenic HPVs. In contrast, almost half of CCs in older patients had low-oncogenic HPVs, suggesting they could depend on the presence of other factors. © 2014 Guardado-Estrada et al.
Filiaciones:
Guardado-Estrada M.:
Univ Nacl Autonoma Mexico, Hosp Gen Mexico, Fac Med, Unidad Med, Mexico City 04510, DF, Mexico
Unidad de Medicina Genómica, Facultad de Medicina, Universidad Nacional Autónoma de México, México, DF, Mexico
Juárez-Torres E.:
Univ Nacl Autonoma Mexico, Hosp Gen Mexico, Fac Med, Unidad Med, Mexico City 04510, DF, Mexico
Unidad de Medicina Genómica, Facultad de Medicina, Universidad Nacional Autónoma de México, México, DF, Mexico
Román-Bassaure E.:
Servicio de Oncología, Hospital General de México, México, DF, Mexico
Medina-Martinez I.:
Univ Nacl Autonoma Mexico, Hosp Gen Mexico, Fac Med, Unidad Med, Mexico City 04510, DF, Mexico
Unidad de Medicina Genómica, Facultad de Medicina, Universidad Nacional Autónoma de México, México, DF, Mexico
Alfaro A.:
Univ Nacl Autonoma Mexico, Hosp Gen Mexico, Fac Med, Unidad Med, Mexico City 04510, DF, Mexico
Unidad de Medicina Genómica, Facultad de Medicina, Universidad Nacional Autónoma de México, México, DF, Mexico
Benuto R.E.:
Academia Mexicana de Dermatología, México, DF, Mexico
Dean M.:
Laboratory of Experimental Immunology, National Cancer Institute, Frederick, MD, United States
Villegas-Sepulveda N.:
Departamento de Biomedicina Molecular, Centro de Investigación y Estudios Avanzados, Instituto Politécnico Nacional, México, DF, Mexico
Berumen J.:
Univ Nacl Autonoma Mexico, Hosp Gen Mexico, Fac Med, Unidad Med, Mexico City 04510, DF, Mexico
Univ Nacl Autonoma Mexico, Fac Med, Dept Expt Med, Mexico City 04510, DF, Mexico
Unidad de Medicina Genómica, Facultad de Medicina, Universidad Nacional Autónoma de México, México, DF, Mexico
Departamento de Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, México, DF, Mexico
All Open Access, Gold
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