Voluntary exercise adapts the hypothalamus- Pituitary-Thyroid axis in male rats
Por:
Uribe, RM, Jaimes-Hoy, L, Ramirez-Martinez, C, Garcia-Vazquez, A, Romero, F, Cisneros, M, Cote-Velez, A, Charli, JL, Joseph-Bravo, P
Publicada:
1 may 2014
Categoría:
Endocrinology
Resumen:
The hypothalamic-pituitary thyroid (HPT) axis modulates energy homeostasis. Its activity decreases in conditions of negative energy balance but the effects of chronic exercise on the axis are controversial and unknown at hypothalamic level. Wistar male rats were exposed for up to 14 days to voluntary wheel running (WR), or pair-feeding (PF; 18% food restriction), or to repeated restraint (RR), a mild stressor. WR and RR diminished food intake; body weight gain decreased in the 3 experimental groups, butWATmass and serum leptin more intensely in theWRgroup. WR, but not RR, produced a delayed inhibition of central markers of HPT axis activity. At day 14, in WR rats paraventricular nucleus-pro-TRH mRNA and serum TSH levels decreased, anterior pituitary TRHreceptor 1 mRNA levels increased, but serum thyroid hormone levels were unaltered, which is consistent with decreased secretion of TRH and clearance of thyroid hormones. A similar pattern was observed if WR animals were euthanized during their activity phase. In contrast, in PF animals the profound drop of HPT axis activity included decreased serum T3 levels and hepatic deiodinase 1 activity; these changes were correlated with an intense increase in serum corticosterone levels. WR effects on HPT axis were not associated with changes in the activity of the hypothalamicpituitary adrenal axis, but correlated positively with serum leptin levels. These data demonstrate that voluntaryWRadapts the status of the HPT axis, through pathways that are distinct from those observed during food restriction or repeated stress. © 2014 by the Endocrine Society.
Filiaciones:
Uribe, RM:
UNAM, Inst Biotecnol, Dept Genet Desarrollo & Fisiol Mol, Cuernavaca 62271, Morelos, Mexico
Jaimes-Hoy, L:
UNAM, Inst Biotecnol, Dept Genet Desarrollo & Fisiol Mol, Cuernavaca 62271, Morelos, Mexico
Ramirez-Martinez, C:
UNAM, Inst Biotecnol, Dept Genet Desarrollo & Fisiol Mol, Cuernavaca 62271, Morelos, Mexico
Garcia-Vazquez, A:
UNAM, Inst Biotecnol, Dept Genet Desarrollo & Fisiol Mol, Cuernavaca 62271, Morelos, Mexico
Romero, F:
UNAM, Inst Biotecnol, Dept Genet Desarrollo & Fisiol Mol, Cuernavaca 62271, Morelos, Mexico
Cisneros, M:
UNAM, Inst Biotecnol, Dept Genet Desarrollo & Fisiol Mol, Cuernavaca 62271, Morelos, Mexico
Cote-Velez, A:
UNAM, Inst Biotecnol, Dept Genet Desarrollo & Fisiol Mol, Cuernavaca 62271, Morelos, Mexico
Charli, JL:
UNAM, Inst Biotecnol, Dept Genet Desarrollo & Fisiol Mol, Cuernavaca 62271, Morelos, Mexico
Joseph-Bravo, P:
UNAM, Inst Biotecnol, Dept Genet Desarrollo & Fisiol Mol, Cuernavaca 62271, Morelos, Mexico
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