Temperature-responsiveness and biocompatibility of DEGMA/OEGMA radiation-grafted onto PP and LDPE films
Por:
Ramírez-Jiménez A., Alvarez-Lorenzo C., Concheiro A., Bucio E.
Publicada:
1 jun 2014
Categoría:
Radiation
Resumen:
Polypropylene (PP) and low density polyethylene (LDPE) were modified by ?-ray grafting of di(ethylene glycol) methyl ether methacrylate (DEGMA) and oligo (ethylene glycol) methyl ether methacrylate (OEGMA300 or OEGMA475 with Mn 300 and 475 respectively) with different monomer concentrations and mol ratios. The grafting percentage was evaluated as a function of the solvent, irradiation dose, reaction time, temperature, and monomers concentration. The grafted materials were more hydrophilic than the pristine polymers, as observed by contact angle and swelling in water. Temperature-responsive behavior was evaluated using DSC showing transitions between 34 and 48. °C. In vitro hemocompatibility, protein adsorption, cytotoxicity and bacteria adhesion tests were also carried out. Overall, the DEGMA/OEGMA grafting provides hemo and cytocompatible materials that exhibit temperature-responsive hydrophilic features and decreased protein adsorption. © 2014 Elsevier Ltd.
Filiaciones:
Univ Nacl Autonoma Mexico, Inst Ciencias Nucl, Dept Quim Radiac & Radioquim, Mexico City 04510, DF, Mexico
Departamento de Farmacia y Tecnología Farmacéutica, Universidad de Santiago de Compostela, 15782, Santiago de Compostela, Spain
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