Potent Anti-Inflammatory Activity of Carbohydrate Polymer with Oxide of Zinc
Por:
Moreno-Eutimio M.A., Nieto-Velázquez N.G., Espinosa-Monroy L., Torres-Ramos Y., Montoya-Estrada A., Cueto J., Hicks J.J., Acosta-Altamirano G.
Publicada:
1 ene 2014
Resumen:
Pebisut is a biological adhesive composed of naturally occurring carbohydrates combined with zinc oxide (ZnO) initially used as a coadjutant for healing of anastomoses. Likewise some works demonstrated that carbohydrate complexes exerts anti-inflammatory activity and it is widely known that ZnO modulate inflammation. However, the direct effects of Pebisut on isolated cells and acute inflammatory responses remained to be investigated. The present study evaluated anti-inflammatory effect of Pebisut using lipopolysaccharide (LPS) stimulated human mononuclear cells, chemotaxis, and cell infiltration in vivo in a murine model of peritonitis. Our data show that human cells treated with different dilutions of Pebisut release less IL-6, IL-1 beta, and IL-8 after LPS stimuli compared with the control treated cells. In addition, Pebisut lacked chemotactic activity in human mononuclear cells but was able to reduce chemotaxis towards CCL2, CCL5, and CXCL12 that are representative mononuclear cells
Filiaciones:
Moreno-Eutimio M.A.:
Immunobiology Laboratory, Mexico's Juarez Hospital, Ministry of Health, 07760 Mexico City, Mexico
Mexico's Juarez Hospital, Ministry of Health, 07760 Mexico City, Mexico
Nieto-Velázquez N.G.:
Immunobiology Laboratory, Mexico's Juarez Hospital, Ministry of Health, 07760 Mexico City, Mexico
Mexico's Juarez Hospital, Ministry of Health, 07760 Mexico City, Mexico
Espinosa-Monroy L.:
Immunobiology Laboratory, Mexico's Juarez Hospital, Ministry of Health, 07760 Mexico City, Mexico
Mexico's Juarez Hospital, Ministry of Health, 07760 Mexico City, Mexico
Torres-Ramos Y.:
Biochemistry Department, National Institute of Perinatology, Ministry of Health, 11000 Mexico City, Mexico
Montoya-Estrada A.:
Biochemistry Department, National Institute of Perinatology, Ministry of Health, 11000 Mexico City, Mexico
Cueto J.:
Health Sciences Faculty, Anahuac University, 52786 State of Mexico, Mexico
Hicks J.J.:
Health Research Policies, Coordinating Commission of National Health Institutes and Highly Specialized Hospitals, 01900 Mexico City, Mexico
Acosta-Altamirano G.:
Mexico's Juarez Hospital, Ministry of Health, 07760 Mexico City, Mexico
All Open Access, Gold
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