5,10-Methylenetetrahydrofolate reductase single nucleotide polymorphisms and gene-environment interaction analysis in non-syndromic cleft lip/palate
Por:
Estandia-Ortega B., Velázquez-Aragón J.A., Alcántara-Ortigoza M.A., Reyna-Fabian M.E., Villagómez-Martínez S., González-del Angel A.
Publicada:
1 abr 2014
Categoría:
Dentistry (miscellaneous)
Resumen:
Non-syndromic cleft lip/palate (NSCL/P) is a common congenital defect in Mexico. Periconceptional intake of folic acid (FA) may reduce the risk of this malformation. Although the 5,10-methylenetetrahydrofolate reductase (MTHFR) enzyme participates in folate metabolism, several studies failed to find any association between NSCL/P and the MTHFR C677T and A1298C polymorphisms. However, interactions among NSCL/P, MTHFR gene polymorphisms, and FA intake have not been explored in Mexican populations. This case-control study included 132 patients with NSCL/P and 370 controls from Mexico City. Maternal FA consumption during pregnancy was examined, as were the MTHFR C677T and A1298C polymorphisms and gene-FA interactions. Maternal FA intake during the periconceptional period was lower in cases (1.5%) than in controls (13%), with the risk of delivering a child with NSCL/P lower in mothers who consumed FA (OR=0.29, 95% CI: 0.19-0.44). In addition, the risk of NSCL/P was lower in children with th
Filiaciones:
Estandia-Ortega B.:
Laboratorio de Biología Molecular, Departamento de Genética Humana, Instituto Nacional de Pediatría, Distrito Federal, Mexico
Velázquez-Aragón J.A.:
Laboratorio de Biología Molecular, Departamento de Genética Humana, Instituto Nacional de Pediatría, Distrito Federal, Mexico
Alcántara-Ortigoza M.A.:
Laboratorio de Biología Molecular, Departamento de Genética Humana, Instituto Nacional de Pediatría, Distrito Federal, Mexico
Reyna-Fabian M.E.:
Laboratorio de Biología Molecular, Departamento de Genética Humana, Instituto Nacional de Pediatría, Distrito Federal, Mexico
Villagómez-Martínez S.:
Unidad de Apoyo a la Investigación Clínica, Instituto Nacional de Pediatría, Distrito Federal, Mexico
González-del Angel A.:
Laboratorio de Biología Molecular, Departamento de Genética Humana, Instituto Nacional de Pediatría, Distrito Federal, Mexico
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