IRS1, TCF7L2, ADRB1, PPARG, and HHEX Polymorphisms Associated with Atherogenic Risk in Mexican Population
Por:
Estrada-Velasco B.I., Cruz M., Madrid-Marina V., Martínez-Nava G.A., Gomez-Zamudio J., Burguete-García A.I.
Publicada:
1 ene 2013
Resumen:
Objective. We aimed to explore the association between polymorphisms of IRS1 (rs1801278), TCF7L2 (rs7903146 and rs12255372), ADRB1 (rs1801253), PPARG (rs1801282), and HHEX (rs5015480) genes with atherogenic risk (AI = Total cholesterol/HDL) inMetS, T2D, and healthy populations from theMexican Social Security Institute. Methodology and Results. Four hundred thirty-fiveMetS, 517 T2D, and 547 healthy individuals were selected. The association between the SNPs and the atherogenic index was evaluated by multiple linear regression andmultinomial logistic regressionmodels. TheADRB1 gene showed a statistically significant association with high-risk atherogenic index, OR = 2.94 (IC 95% 1.64-5.24; P< 0.0001) for the Arg/Gly variant, under the dominant model an OR = 2.96 (IC 95% 1.67-5.25; P< 0.0001), and under the Log additive model an OR = 2.52 (IC 95% 1.54-4.15; P< 0.0001). Conclusions. The Arg389Gly polymorphismof the ADRB1 gene may be a worthy biological marker to predict the risk of develop
Filiaciones:
Estrada-Velasco B.I.:
Centro de Enfermedades Infecciosas, Instituto Nacional de Salud Pública, Avenida Universidad 655, Santa-Maria Ahuacatitlan, Cuernavaca, 62100 Cuernavaca, Mexico
Cruz M.:
Unidad de Investigación Médica en Bioquímica, Hospital de Especialidades, IMSS, Avenida Cuauhtemoc 330, Doctores, Cuauhtemoc, 06720 México, DF, Mexico
Madrid-Marina V.:
Centro de Enfermedades Infecciosas, Instituto Nacional de Salud Pública, Avenida Universidad 655, Santa-Maria Ahuacatitlan, Cuernavaca, 62100 Cuernavaca, Mexico
Martínez-Nava G.A.:
Centro de Enfermedades Infecciosas, Instituto Nacional de Salud Pública, Avenida Universidad 655, Santa-Maria Ahuacatitlan, Cuernavaca, 62100 Cuernavaca, Mexico
Gomez-Zamudio J.:
Unidad de Investigación Médica en Bioquímica, Hospital de Especialidades, IMSS, Avenida Cuauhtemoc 330, Doctores, Cuauhtemoc, 06720 México, DF, Mexico
Burguete-García A.I.:
Centro de Enfermedades Infecciosas, Instituto Nacional de Salud Pública, Avenida Universidad 655, Santa-Maria Ahuacatitlan, Cuernavaca, 62100 Cuernavaca, Mexico
All Open Access, Gold
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