SPINAL LTP INDUCED BY SCIATIC NERVE ELECTRICAL STIMULATION ENHANCES POSTERIOR TRIANGULAR THALAMIC NOCICEPTIVE RESPONSES
Por:
González-Hernández A., Martínez-Lorenzana G., Rojas-Piloni G., Rodríguez-Jiménez J., Hernández-Linares Y., Villanueva L., Condés-Lara M.
Publicada:
27 mar 2013
Categoría:
Neuroscience (miscellaneous)
Resumen:
Long-term potentiation (LTP) can be induced by electrical stimulation and gives rise to an increase in synaptic strength at the first relay. This phenomenon has been associated with learning and memory and also could be the origin of several pathological states elicited by an initial strong painful stimulus, such as some forms of neuropathic pain. We used high-frequency electrical stimulation of the sciatic nerve in anesthetized rats to produce spinal LTP. To evaluate the effect of spinal LTP on the activity of neurons in the posterior triangular nucleus of the thalamus (POT), we applied an electrical stimulation (40 stimuli; 1 ms; 0.5 Hz; 1.5 mA) to cutaneous tissues at 10-min intervals during at least 3 h. In the majority of cases, PoT cells did not respond to cutaneous stimulation before LTP, but 50 min after LTP induction PoT cells progressively began responding to the cutaneous stimulation. Furthermore, after 3 h of LTP induction, PoT neurons could respond to cutaneous stimulation
Filiaciones:
González-Hernández A.:
Univ Nacl Autonoma Mexico, Dept Neurobiol Desarrollo & Neurofisiol, Inst Neurobiol, Queretaro 76230, Mexico
Martínez-Lorenzana G.:
Univ Nacl Autonoma Mexico, Dept Neurobiol Desarrollo & Neurofisiol, Inst Neurobiol, Queretaro 76230, Mexico
Rojas-Piloni G.:
Univ Nacl Autonoma Mexico, Dept Neurobiol Desarrollo & Neurofisiol, Inst Neurobiol, Queretaro 76230, Mexico
Rodríguez-Jiménez J.:
Univ Nacl Autonoma Mexico, Dept Neurobiol Desarrollo & Neurofisiol, Inst Neurobiol, Queretaro 76230, Mexico
Hernández-Linares Y.:
Univ Nacl Autonoma Mexico, Dept Neurobiol Desarrollo & Neurofisiol, Inst Neurobiol, Queretaro 76230, Mexico
Villanueva L.:
Centre de Psychiatrie et Neurosciences, INSERM UMR 894, París, France
Condés-Lara M.:
Univ Nacl Autonoma Mexico, Dept Neurobiol Desarrollo & Neurofisiol, Inst Neurobiol, Queretaro 76230, Mexico
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