A New Parasiticidal Compound in T. solium Cysticercosis
Por:
Hernández-Bello R., Escobedo G., Carrero J.C., Cervantes-Rebolledo C., Dowding C., Frincke J., Reading C., Morales-Montor J.
Publicada:
1 ene 2013
Resumen:
The effect of 16 alpha-bromoepiandrosterone (EpiBr), a
dehydroepiandrosterone (DHEA) analogue, was tested on the cysticerci of
Taenia solium, both in vitro and in vivo. In vitro treatment of T.
solium cultures with EpiBr reduced scolex evagination, growth, motility,
and viability in dose- and time-dependent fashions. Administration of
EpiBr prior to infection with T. solium cysticerci in hamsters reduced
the number and size of developed taenias in the intestine, compared with
controls. These effects were associated to an increase in splenocyte
proliferation in infected hamsters. These results leave open the
possibility of assessing the potential of this hormonal analogue as a
possible antiparasite drug, particularly in cysticercosis and taeniosis.
Filiaciones:
Hernández-Bello R.:
Univ Nacl Autonoma Mexico, Dept Inmunol, Inst Invest Biomed, Mexico City 04510, DF, Mexico
Escobedo G.:
Unidad de Medicina Experimental, Hospital General de México, 06726 México, DF, Mexico
Carrero J.C.:
Univ Nacl Autonoma Mexico, Dept Inmunol, Inst Invest Biomed, Mexico City 04510, DF, Mexico
Cervantes-Rebolledo C.:
Univ Nacl Autonoma Mexico, Dept Inmunol, Inst Invest Biomed, Mexico City 04510, DF, Mexico
Dowding C.:
Hollis-Eden Pharmaceuticals, Inc., San Diego, CA 92121, United States
Frincke J.:
Univ Nacl Autonoma Mexico, Dept Inmunol, Inst Invest Biomed, Mexico City 04510, DF, Mexico
Reading C.:
Hollis-Eden Pharmaceuticals, Inc., San Diego, CA 92121, United States
Morales-Montor J.:
Departamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, AP 70228, 04510 México, DF, Mexico
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