Potential role of sirtuins in livestock production
Por:
Ghinis-Hozumi Y., Antaramian A., Villarroya F., Pina, E, Mora O.
Publicada:
1 ene 2013
Categoría:
Animal Science and Zoology
Resumen:
Sirtuins are NAD(+)-dependent histone and protein deacetylases, which
have been studied during the last decade with a focus on their role in
lifespan extension and age-related diseases under normal and
calorie-restricted or pathological conditions. However, sirtuins also
have the ability to regulate energy homeostasis as they can sense the
metabolic state of the cell through the NAD(+)/NADH ratio; hence,
changes in the diet can modify the expression of these enzymes. Dietary
manipulations are a common practice currently being used in livestock
production with favorable results, probably due in part to the enhanced
activity of sirtuins. Nevertheless, sirtuin expression in livestock
species has not been a research target. For these reasons, the goal of
this review is to awaken interest in these enzymes for future detailed
characterization in livestock species by presenting a general
introduction to what sirtuins are, how they work and what is known about
their role in livestock.
Filiaciones:
Univ Nacl Autonoma Mexico, Programa Posgrado Ciencias Prod & Salud Anim, Mexico City 04510, DF, Mexico
Univ Nacl Autonoma Mexico, Inst Neurobiol, Queretaro 76230, Qro, Mexico
Univ Nacl Autonoma Mexico, Dept Bioquim, Fac Med, Mexico City 04510, DF, Mexico
Departamento de Bioquímica y Biología Molecular e Instituto de Biomedicina (IBUB), Univ. de Barcelona y Ctro. de Invest. Biomedica en Red Fisiopatologia de la Obesidad y Nutricion, Avenida Diagonal 645, Barcelona 08028, Spain
Laboratorio de Rumiología y Metabolismo Nutricional (RuMeN), Secretaría de Posgrado, Universidad Nacional Autónoma de México, Boulevard Bernardo Quintana 514-D, Colonia Arboledas, Querétaro, Qro. 76140, Mexico
All Open Access, Hybrid Gold
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