Interactions of sulforaphane and dimethyl sulfoxide with methyl methanesulfonate, urethane, 4-nitroquinoline-1-oxide and hydrogen peroxide in the Drosophila melanogaster wing sp
Por:
Duenas-Garcia, IE, Santos-Cruz, LF, Castaneda-Partida, L, Castaneda-Sortibran, AN, Ordaz-Tellez, MG, Sanchez-Santos, A, Duran-Diaz, A, Rodriguez-Arnaiz, R, Heres-Pulido, ME
Publicada:
1 dic 2012
Resumen:
Sulforaphane (SF) is an isothiocyanate present in Brassicaceae, vegetables that induce the detoxification of electrophiles and reactive oxygen species. SF has been correlated with chemoprevention mechanisms against degenerative diseases. We tested if the SF had an effect against methyl methanesulfonate (MMS), urethane (URE), 4-NQO and H2O2. SF (>95% purity, 0.14, 0.28, 0.56 mm) was diluted in a DMSO/Tw80/EtOH mixture (DTE) corresponding to 25, 50, 100% of lyophilized broccoli. The SF treatment (0.14 mM) was positive for small spots in the ST cross and negative in the HB cross. In the HB cross, SF (0.28 mM) was genotoxic. In the ST cross, the SF treatments showed a tendency to reduce the genotoxic damage caused by MMS, which could be explained by the radical scavenging action of the DTE mixture. In the ST cross, the frequency of small spots in the SF 0.14 mM/URE treatment was similar to that of Water/URE, which can be explained by a DTE and SF scavenger action. In both crosses, the resu
Filiaciones:
Duenas-Garcia, IE:
Univ Nacl Autonoma Mexico, FES Iztacala, Tlalnepantla 54090, Estado Mexico, Mexico
Santos-Cruz, LF:
Univ Nacl Autonoma Mexico, FES Iztacala, Tlalnepantla 54090, Estado Mexico, Mexico
Castaneda-Partida, L:
Univ Nacl Autonoma Mexico, FES Iztacala, Tlalnepantla 54090, Estado Mexico, Mexico
Castaneda-Sortibran, AN:
Univ Nacl Autonoma Mexico, Fac Ciencias, Mexico City 04510, DF, Mexico
Ordaz-Tellez, MG:
Univ Nacl Autonoma Mexico, Fac Ciencias, Mexico City 04510, DF, Mexico
Sanchez-Santos, A:
Univ Nacl Autonoma Mexico, FES Iztacala, Tlalnepantla 54090, Estado Mexico, Mexico
Duran-Diaz, A:
Univ Nacl Autonoma Mexico, FES Iztacala, Tlalnepantla 54090, Estado Mexico, Mexico
Rodriguez-Arnaiz, R:
Univ Nacl Autonoma Mexico, Fac Ciencias, Mexico City 04510, DF, Mexico
Heres-Pulido, ME:
Univ Nacl Autonoma Mexico, FES Iztacala, Tlalnepantla 54090, Estado Mexico, Mexico
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